Results 81 to 90 of about 964,701 (265)
Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance [PDF]
Oxidative Medicine and Cellular Longevity, 2018 Insulin resistance (IR), a key component of the metabolic syndrome, precedes the development of diabetes, cardiovascular disease, and Alzheimer’s disease. Its etiological pathways are not well defined, although many contributory mechanisms have been established.
openaire +2 more sources
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Genome BiologyBackground Polyploidy contains multiple gene copies, known as homoeologs. Differential expression of homoeologs confers expression plasticity and facilitates the adaptation and domestication of major polyploid crops.
Xiaoming Wang +10 more
doaj +1 more source
Stress and resistance to stress of students
RUDN Journal of Ecology and Life Safety, 2013 Concepts of a stress and resistance to stress are considered. The review of researches in the field of studying of a stress and methods of increase of a resistance to stress of students of higher educational institutions is carried out, and also the actual directions of research in these areas are defined.
openaire +1 more source
Mechanism of Resistance to Oxidative Stress in Doxorubicin Resistant Cells.
Biological and Pharmaceutical Bulletin, 2001 Doxorubicin (DOX) is an anthracycline drug widely used in chemotherapy for cancer patients, but it often gives rise to multidrug resistance in cancer cells. The purpose of this work was to study the effect of hydrogen peroxide in DOX-sensitive mouse P388/S leukemia cells and in the DOX-resistant cell line.
FURUSAWA, Shinobu +9 more
openaire +3 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
In vitro method for early evaluation of nitrogen use efficiency associated traits in potato
Journal of Applied Botany and Food Quality, 2014 The objective of the present study was to characterize various traits associated with nitrogen uptake and utilization in a range of potato cultivars. For this purpose an in vitro test system was developed which allows analyzing specific stress responses ...
Annegret Schum, Gisela Jansen
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Nature CommunicationsHost-derived reactive oxygen species (ROS) are an important defense means to protect against pathogens. Although mitochondria are the main intracellular targets of ROS, how pathogens regulate mitochondrial physiology in response to oxidative stress ...
Wenhao Li +6 more
doaj +1 more source