Results 81 to 90 of about 972,765 (265)
Phytopathology ResearchWheat stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is a major global threat to wheat production, severely affecting yield stability.
Jierong Wang +7 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Epitranscriptomic RNA editing resolves Mus81 DNA repair tradeoffs in heat tolerance and meiosis
Nature CommunicationsMaintaining genome integrity is essential, yet how DNA repair is balanced across life stages remains poorly understood. Here we uncover an epitranscriptomic mechanism in the fungal pathogen Fusarium graminearum that alleviates a trade-off between heat ...
Mengchun Wu +8 more
doaj +1 more source
Crop JournalHeat stress is a major threat to maize (Zea mays L.) production worldwide. Heat shock transcription factors (HSFs) play vital roles in plant responses to heat stress.
Jing Wang +8 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Mechanism of tea infusion as a novel control agent against Fusarium graminearum
Phytopathology ResearchFusarium head blight (FHB), caused by Fusarium graminearum, severely reduces wheat yield and grain quality due to deoxynivalenol (DON) contamination. To develop sustainable alternatives to synthetic fungicides, we evaluated the antifungal activity of tea
Ying Li +7 more
doaj +1 more source
PlantsGrapevine (Vitis vinifera L.) is a key fruit crop affected by abiotic stresses such as salinity, drought, and temperature extremes. The Regulator of Chromosome Condensation 1 (RCC1) family, involved in regulating Ran GTPase activation, nucleocytoplasmic ...
Hamza Ali +12 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source