Results 161 to 170 of about 4,906,635 (333)

A novel GWAS locus influences microvascular response to mental stress and predicts adverse cardiovascular events [PDF]

Zakaria Almuwaqqat, Chang Liu, Jeong Hwan Kim, Muhammad Hammadah, Ayman Alkhoder, Paolo Raggi, Amit Shah, J. Douglas Bremner, Viola Vaccarino, Yan V. Sun, Arshed A. Quyyumi   +10 more
openalex   +1 more source

Mission load dynamic tests of two undensified Space shuttle thermal protection system tiles [PDF]

Two tests of undensified Space Shuttle thermal protection tiles under combined static and dynamic loads were conducted. The tiles had a density of approximately 144 Kg/cum (LI900 tiles) and were mounted on a strain isolation pad which was 0.41 cm (.160 ...
Gowdey, J. C., Leatherwood, J. D.
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Hormesis as a Particular Type of Plant Stress Response. [PDF]

Plants (Basel)
Siemieniuk A, Rudnicka M, Jemioła G, Małkowski E.   +3 more
europepmc   +1 more source

Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways

, 2012
Patrick T. Grogan, Kristina D. Sleder, Abbas Samadi, Huaping Zhang, Barbara N. Timmermann, Mark S. Cohen   +5 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Metabolic pathways regulated by TAp73 in response to oxidative stress

, 2016
Massimiliano Agostini, Margherita Annicchiarico‐Petruzzelli, Gerry Melino, Alessandro Rufini   +3 more
openalex   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Termination of the integrated stress response. [PDF]

Science
De Miguel C, Thorkelsson SR, Fatalska A, Hodgson G, Wang C, Bertolotti A.   +5 more
europepmc   +1 more source

Prohexadione Calcium and Gibberellin Improve Osmoregulation, Antioxidant Response and Ion Homeostasis to Alleviate NaCl Stress in Rice Seedlings [PDF]

Meiling Liu, Naijie Feng, Dianfeng Zheng, Rongjun Zhang   +3 more
openalex   +1 more source