Results 121 to 130 of about 9,272,105 (348)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

An integrated analysis of mineralogical and microstructural characteristics and petrophysical properties of carbonate rocks in the lower Indus Basin, Pakistan

Open Geosciences, 2019
Carbonate rocks are believed to be proven hydrocarbon reservoirs and are found in various basins of Pakistan including Lower Indus Basin. The carbonate rock intervals of the Jakkher Group from Paleocene to Oligocene age are distributed in south-western ...
Ali Abro Waheed, Majeed Shar Abdul, Sang Lee Kun, Ali Narejo Asad   +3 more
doaj   +1 more source

Post-buckling behavior of cylinders in torsion [PDF]

Stress analysis of initial post-buckling behavior and imperfection sensitivity of thin walled cylinders in ...
Budiansky, B.
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A Coupled Multi-Mechanism Modeling Study for the Fractured Horizontal Well in Shale Oil Reservoirs

Energies
Shale oil reservoirs are characterized by ultra-low matrix permeability. After large-scale hydraulic fracturing is applied to horizontal wells, fluid transport becomes highly complex, posing major challenges for accurately predicting production ...
Yilin Ren, Jianming Fan, Zunrong Xiao, Fulin Liu, Xuze Zhang, Yuan Zhang, Ye Tian   +6 more
doaj   +1 more source

Experimental Study on the Stress Sensitivity and Influence Factors of Shale under Varying Stress

Shock and Vibration, 2018
Shale reservoirs are characterized by extremely low permeability and high clay content. To further study the stress sensitivity of a shale reservoir, the Lower Cambrian shale in north Guizhou was utilized.
Zhonghu Wu, Yu-jun Zuo, Shanyong Wang, Jibin Sunwen, Leilei Liu   +4 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

An interpretable XGBoost-based transfer learning framework for stress-sensitive pore volume compressibility prediction in carbonate rocks

Frontiers in Earth Science
Pore volume compressibility (PVC) is a key petrophysical parameter controlling the mechanical response and production performance of reservoir rocks.
Kaijun Tong, Xue Qin, Xue Qin, Biao Zhang, Junshuai Jiang, Zhi Luo, Wensheng Luo   +6 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Experimental Investigation of Permeability Sensitivity of Coal Reservoir to Reservoir Pressure and Its Fluid–Solid Coupling Control Mechanism

Energies
During coalbed methane (CBM) production, coal reservoir pore/fracture structure varies dynamically under the action of fluid–solid coupling. And coal reservoir permeability changes accordingly.
Xiaokai Xu, Yue Xin, Qingchao Li, Shuo Zhang, Lin Tian, Zhengzheng Xue   +5 more
doaj   +1 more source