Results 31 to 40 of about 203,873 (264)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Advances in Mechanical Engineering, 2021 To predict and minimize machining distortion in the manufacturing process, bulk residual stresses in aeronautical components with distinct geometries were investigated via experimental mechanics and numerical simulation.
Zheng Zhang +3 more
doaj +1 more source
System-Wide Stress Simulation [PDF]
SSRN Electronic Journal, 2019 We present a model for assessing how the UK’s system of market-based finance — an increasingly important source of credit to the real economy since the financial crisis — might behave under stress. The core of this model is a set of representative agents, which correspond to key sectors of the UK’s financial system.
David Aikman +5 more
openaire +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
PLoS ONE, 2019 BackgroundSimulations in healthcare reproduce clinical situations in stressful conditions. Repeated stress exposure might influence the learning process in simulation as well as real-life.Objectives1) To record heart rate and heart rate variability ...
Daniel Aiham Ghazali +6 more
doaj +1 more source
Sub-modeling approach for obtaining structural stress histories during dynamic analysis [PDF]
Mechanical Sciences, 2013 Modern machine structures are often fabricated by welding. From a fatigue point of view, the structural details and especially, the welded details are the most prone to fatigue damage and failure.
T. T. Rantalainen +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Numerical simulation of thermal stress fluctuation at a mixing tee for thermal fatigue problems
Mechanical Engineering Journal, 2018 Thermal fatigue cracks have been found at mixing tees in nuclear power plants. The mixing flow of high and low temperature fluids causes temperature and stress fluctuations in the pipe wall and these result in fatigue crack initiation.
Koji MIYOSHI +3 more
doaj +1 more source
Stress responses in high-fidelity simulation and standard simulation training among medical students
BMC Medical Education, 2023 Background Simulation has been recognized as a shift in healthcare education that can improve skills and patient safety and outcomes. High-fidelity simulation of critical medical situations can be a source of stress among participants that can interfere ...
Pamela Barbadoro +10 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source