Results 131 to 140 of about 807,773 (347)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Assessment of residual stress using thermoelastic stress analysis

open access: yes, 2011
The work described in this thesis considers the application of thermoelastic stress analysis (TSA) to theassessment of residual stresses in metallic materials. Residual stresses exist within almost all engineeringcomponents and structures.
Robinson, Andrew Ferrand
core  

Limitations in instrumental activities of daily living among community dwelling older adults in Kerala, India

open access: yesDiscover Public Health
Introduction Instrumental Activities of Daily Living (IADL) are complex functional tasks essential for independent community living. Assessing IADL limitations is especially important in Kerala state of India, which has a rapidly aging population, high ...
P. R. Veena Mohan, G. K. Mini
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

The affects of forgiveness on the symptoms of posttraumatic stress disorder as a result of sexual trauma [PDF]

open access: yes, 2007
This study continues research pertaining to the affects of forgiveness on Posttraumatic Stress Disorder (PTSD) symptoms resulting from sexual trauma. The research question asked whether or not the ability to forgive would reduce, increase, or have no ...
Johnston, Sandra K., Sandra K. Johnston
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Shock compression of water and solutions of ammonium nitrate

open access: yes, 2011
Modern mining explosives employ solutions of ammonium nitrate, where the solution is the oxidising component of a fuel/oxidiser mixture. This thesis is primarily concerned with the shock response of water and of aqueous solutions of ammonium nitrate.

core   +1 more source

Stress Path Dependence of Mechanical Properties of Saturated Soft Loess and its Simulation

open access: yesTaiyuan Ligong Daxue xuebao
[Purposes] The saturated soft loess formed by the rise of groundwater level is mostly in a soft plastic and flow plastic state, with engineering geological characteristics of high water content, high compression, and low bearing capacity.
LI Shixiong   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Strain-Rate Effects and Stress-State Dependence of the Initial Stiffness of Remolded Loess

open access: yes工程科学与技术
Objective The initial stiffness of loess in the small-strain range is important for deformation analysis and constitutive modeling. For remolded loess, the effects of specimen preparation, strain rate, stress state, and stress history on initial ...
WANG Jinyuan, OUYANG Yong, ZHI Peixiang
doaj  

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