Results 101 to 110 of about 4,720,489 (310)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Bearing Capacity Assessment for the Mast of Offshore Workover Rig Based on Stress Measurement

open access: yesShiyou jixie, 2015
The mast bearing capacity is mainly assessed by conventional methods of stress test method or finite element method.The stress test method or finite element method alone presents the issue of incomprehensive rod study and making necessary assumptions ...
Zhang Xiaodong   +4 more
doaj  

Possible correlation between work-hardening and fatigue-failure [PDF]

open access: yes, 1969
Conceptual theory proposes that cyclic hardening due to non-uniform strain and stress amplitudes during testing, especially during the initial application of stress to a specimen, may correlate positively with the ultimate strength of the specimen under ...
Kettunen, P. O., Kocks, U. F.
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Application of Hertzian Tests to Measure Stress–Strain Characteristics of Ceramics at Elevated Temperatures [PDF]

open access: bronze, 2006
Estíbaliz Sánchez‐González   +5 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

CRISES WARNING MODEL - STRESS TEST. ALBANIAN CASE [PDF]

open access: yes
Risk is a permanent companion of any business, including also the banks, which have the objective of managing the money entrusted by the depositors. The effectiveness of this management requires safe and profitable transfer of money between the giver and
Doriana Matraku
core  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

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