Results 121 to 130 of about 21,350,036 (395)

Right Heart Catheterisation with Dobutamine Stress Test for Evaluation of Right Ventricular Outflow Tract Obstruction 30 Years After Surgical Repair of Tetralogy of Fallot [PDF]

, 2022
Kengo Yasuda, Tomomi Watanabe, Aiko Takami, Toshihiko Akasaka, Yasushi Yoshikawa, Motonobu Nishimura, Kazuhiro Yamamoto   +6 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Bearing Capacity Assessment for the Mast of Offshore Workover Rig Based on Stress Measurement

Shiyou jixie, 2015
The mast bearing capacity is mainly assessed by conventional methods of stress test method or finite element method.The stress test method or finite element method alone presents the issue of incomprehensive rod study and making necessary assumptions ...
Zhang Xiaodong, Wu Han, Jiang genhua, Chen Yuhai, Hua Jian   +4 more
doaj  

Economic Volatility Stress Tests for Trade Shocks Under the Pressure of Anti-Globalisation [PDF]

, 2023
Tixin Li
openalex   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Introduction of Internal Circulation-Based Cooling Methods and Green Coolants in Milling via Cutting Tool and Tooling Design

Applied Sciences
This paper describes the process of the design and verification of a milling tool and tooling that may contribute to the renouncement of the flood cooling method when mineral oils and oil-in-water emulsions are used as coolants.
Ilia Radchenko, Wataru Takahashi, Hidebumi Takahashi, Taro Abe, Hiroyuki Sasahara   +4 more
doaj   +1 more source

Conceptual and Statistical Issues Regarding the Probability of Default and Modeling Default Risk [PDF]

Database Systems Journal, 2011
In today’s rapidly evolving financial markets, risk management offers different techniques in order to implement an efficient system against market risk.
Emilia TITAN, Adela Ioana TUDOR
doaj  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Stress testing social and governance risks: the potential of ESG rating agencies [PDF]

Risk Management Magazine
Recently, there has been a growing focus on sustainability issues within the financial sector. However, quantitative analysis of social and governance aspects has been challenging due to difficulties in data modelling.
Simone Valletta
doaj   +1 more source