Results 81 to 90 of about 21,350,036 (395)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Identifying the Causes of Unexplained Dyspnea at High Altitude Using Normobaric Hypoxia with Echocardiography

Journal of Imaging
Exposure to high altitude results in hypobaric hypoxia, leading to physiological changes in the cardiovascular system that may result in limiting symptoms, including dyspnea, fatigue, and exercise intolerance.
Jan Stepanek, Juan M. Farina, Ahmed K. Mahmoud, Chieh-Ju Chao, Said Alsidawi, Chadi Ayoub, Timothy Barry, Milagros Pereyra, Isabel G. Scalia, Mohammed Tiseer Abbas, Rachel E. Wraith, Lisa S. Brown, Michael S. Radavich, Pamela J. Curtisi, Patricia C. Hartzendorf, Elizabeth M. Lasota, Kyley N. Umetsu, Jill M. Peterson, Kristin E. Karlson, Karen Breznak, David F. Fortuin, Steven J. Lester, Reza Arsanjani   +22 more
doaj   +1 more source

Basic Indicators of Systemic Risk in the EU Banking Sector. Implications for Banking Regulation

International Journal of Management and Economics, 2015
The issue of systemic risk regulation and management has gained substantial attention following the latest financial crisis. In the case of the EU it became crucial to deal with the systemic risk problem on a supranational level since the banking sectors
Sum Katarzyna
doaj   +1 more source

Shock adhesion test for composite bonded assembly using a high pulsed power generator [PDF]

, 2013
In a context of the rising use of composite assemblies in aeronautic or defense fields, the assessment of their strength is a key issue. The method developed in this study attempts to provide solutions.
ARRIGONI, Michel, BERTHE, Laurent, BOUSTIE, Michel, BUZAUD, Eric, GAY, Elise   +4 more
core   +6 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Field Emission Air-Channel Devices as a Voltage Adder

Nanomaterials, 2020
Field emission air-channel (FEAC) devices can work under atmospheric pressure with a low operation voltage when the electron channel is far less than the mean free path (MFP) in the air, thereby making them a practical component in circuits.
Wen-Teng Chang, Ming-Chih Cheng, Tsung-Ying Chuang, Ming-Yen Tsai   +3 more
doaj   +1 more source

Prospective Analysis of Stress and Immunity in Advanced Cancer [PDF]

, 2011
Objectives:The aims of this study were to assess chronic stress in a sample of advanced cancer patients, test the association between stress and NK cell immune markers over time, and examine whether stress predicts immune markers over time.Methods:A ...
Ikpeama, Uzoh Erick
core   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Actual aspects of preoperative examination in planned extracardiac interventions: A review

Consilium Medicum
In this article, we present an overview of studies conducted in recent years to determine the prognostic value of various diagnostic methods at the stage of preoperative examination and risk prediction in various planned extracardiac interventions, based
Petr Sh. Chomakhidze, Naida K. Kurbanalieva, Alim A. Nebezhev, Vsevolod P. Sedov, Abram L. Syrkin   +4 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source