Results 81 to 90 of about 4,720,489 (310)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Predicting Mutual Fund Stress Levels Utilizing SEBI’s Stress Test Parameters in MidCap and SmallCap Funds Using Deep Learning Models

Risks
: The Association of Mutual Funds of India (AMFI), under the direction of the Securities and Exchange Board of India (SEBI), provided open access to various risk parameters with respect to MidCap and SmallCap funds for the first time from February 2024 ...
Suneel Maheshwari, Deepak Raghava Naik
doaj   +1 more source

Relationship between Cognitive Functions and Hormones [PDF]

, 2013
Stress has been implicated by recent research to significantly contribute towards many cognitive and physiological deficiencies. One of the most popular topics of study is the effect of stress on inhibition, the all-or-none decision about an action or ...
Miao, Daniel C.
core   +1 more source

Using coloured filters to reduce the symptoms of visual stress in children with reading delay [PDF]

, 2015
Background: Meares Irlen Syndrome (MIS), otherwise known as “visual stress”, is one condition that can cause difficulties with reading. Aim: This study aimed to compare the effect of two coloured-filter systems on the symptoms of visual stress in ...
Allen PM, American Occupational Therapy Association, Borsting EJ, Bouldoukian J, Evans B, Every Child a Chance Trust, Handler SM, Harris D, John Stein, Konarski M, Kruk R, Maclachlan A, Menacker S, Nicola Ray, Priscilla Harries, Ray NJ, Robinson GL, Roger Hall, Stein JF, Whiteford G, Wilkins AJ, Wilkins AJ   +21 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Introduction of Internal Circulation-Based Cooling Methods and Green Coolants in Milling via Cutting Tool and Tooling Design

Applied Sciences
This paper describes the process of the design and verification of a milling tool and tooling that may contribute to the renouncement of the flood cooling method when mineral oils and oil-in-water emulsions are used as coolants.
Ilia Radchenko, Wataru Takahashi, Hidebumi Takahashi, Taro Abe, Hiroyuki Sasahara   +4 more
doaj   +1 more source

Cloud-Based Online Ageing Monitoring for IoT Devices

IEEE Access, 2019
Reliability of an electronic device, concerning if it can function reliably over its designated lifetime in the field (such as 10 or 15 years), has become more and more important in today's safety-critical applications such as automotive electronics ...
Guan-Hao Lian, Wei-Yi Chen, Shi-Yu Huang
doaj   +1 more source

Can an Evaluation of Students’ Stress Levels Help us Manage Anxiety During OSCEs and Other Assessment Modalities? [PDF]

, 2018
With an increased awareness of mental health issues, in both the student population and the veterinary profession in general, it is important that we obtain a greater understating of the stress experienced by students so as to better prepare them to deal
Dowell, Fiona, Evans, Neil, Hecker, Kent, Krigolson, Olav E., Marshall, Zamantha, Wolfe, Lissann   +5 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Characterization of two new degradation products of atorvastatin calcium formed upon treatment with strong acids

Beilstein Journal of Organic Chemistry, 2019
Atorvastatin calcium (Lipitor®, Sortis®) is a well-established cholesterol synthesis enzyme (CSE) inhibitor commonly used in the therapy of hypercholesterolemia.
Jürgen Krauß, Monika Klimt, Markus Luber, Peter Mayer, Franz Bracher   +4 more
doaj   +1 more source