Results 101 to 110 of about 2,376,179 (319)

System reliability and risk assessment task goals and status [PDF]

The major focus for continued development of the Numerical Evaluation of Stochastic Structures Under Stress (NESSUS) codes is in support of system testing and certification of advanced propulsion systems.
Cruse, T. A., Mahadevan, S.
core   +1 more source

Standardized Testing of Non-Standard Photovoltaic Pavement Surfaces [PDF]

, 2016
Emerging photovoltaic products have expanded the applications for the technologies into markets previously unconsidered for what was thought to be a delicate electronic product.
Coutu, Ronald A., Jr., Lake, Robert A., Nussbaum, John H.   +2 more
core   +2 more sources

Software testing for the CTA observation execution system

Astronomical Telescopes + Instrumentation, 2018
The Cherenkov Telescope Array (CTA) will be the next-generation ground-based instrument for detecting veryhigh energy gamma rays. It will consist of roughly 100 telescopes of different sizes and designs.
T. Murach, A. Zagar, Urban Leben, I. Oya, M. Füssling, D. Dežman, V. Conforti, F. Krack, E. Lyard, D. Melkumyan, K. Mosshammer, I. Sadeh, T. Schmidt, U. Schwanke, J. Schwarz, S. Wiesand   +15 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

CORRECTING ACCOUNTING RESULTS OF TENSIONS USING FEM BY HSS METHOD

Nauka ta progres transportu, 2011
The usage of the Hot Spot Stress (HSS) method by means of linear surface extrapolation (LSE) approach was analyzed for the correction of results of the Finite-Element Method (FEM) in case of singularity of stresses.
D. O. Bannikov, A. E. Huslista
doaj  

Validation of a wide plate finite element model using digital image correlation [PDF]

, 2011
To investigate the influence of global plastic deformations on girth weld defect tolerance in pipelines, a parametric finite element model has been developed. This paper provides an experimental validation of the model.
De Keyser, Karel, De Waele, Wim, Denys, Rudi, Hertelé, Stijn, Van Acker, Frederik, Verstraete, Matthias   +5 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Prediction of mechanical fatigue caused by multiple random excitations [PDF]

, 2004
A simulation method is presented for the fatigue analysis of automotive and other products that are subjected to multiple random excitations. The method is denoted as frequency domain stress-life fatigue analysis and was implemented in the automotive ...
Boer, A. de, Bonte, M.H.A., Liebregts, R.   +2 more
core   +2 more sources