Results 111 to 120 of about 1,221,683 (286)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Design and experimental validation of MMM-based pipeline stress concentration detection system
Results in EngineeringAn intelligent pipeline stress concentration detection system was developed based on the Metal Magnetic Memory (MMM) method, utilizing high-sensitivity anisotropic magnetoresistive (AMR) sensors (HMC5883L).
Deng Gong, Lunwu Zhao, Gang Han
doaj +1 more source
Nigerian Journal of Technological Development, 2021 Aluminium Silicon Carbide (AlSiC) composite materials are used in the electronics industries and other manufacturing companies hence, manufacturing of AlSiC composite materials with the right properties for different applications are vital to most ...
Mathias Ekpu
doaj
Microstructure-based model for the stress-strain relationship of hot-rolled dual-phase steel
工程科学学报, 2015 The microstructure of hot-rolled dual-phase steel was studied by scanning electron microscopy(SEM) and transmission electron microscopy(TEM). The volume fraction of each phase in the dual-phase steel was determined by Image-Pro Plus software.
PANG Qi-hang, TANG Di, ZHAO Zheng-zhi
doaj +1 more source
Performance testing of a low power consumption wireless sensor communication system integrated with an energy harvesting power source [PDF]
, 2012 This paper presents the performance testing results of a wireless sensor communication system with low power consumption integrated with a vibration energy harvesting power source.
Giuliano, Alessandro +4 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Uncovering Bugs in Distributed Storage Systems during Testing (not in Production!) [PDF]
, 2015 Testing distributed systems is challenging due to multiple sources of nondeterminism. Conventional testing techniques, such as unit, integration and stress testing, are ineffective in preventing serious but subtle bugs from reaching production.
Chen, S +10 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source