Results 121 to 130 of about 2,376,179 (319)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Macroscopic fe-simulation of residual stresses in thermo-mechanically processed steels considering phase transformation effects [PDF]
, 2019 Residual stresses are an important issue as they affect both the manufacturing processes as well as the performance of the final parts. Taking into account the whole process chain of hot forming, the integrated heat treatment provided by a defined ...
Behrens, B. A., Chugreev, A., Kock, C.
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Design and experimental validation of MMM-based pipeline stress concentration detection system
Results in EngineeringAn intelligent pipeline stress concentration detection system was developed based on the Metal Magnetic Memory (MMM) method, utilizing high-sensitivity anisotropic magnetoresistive (AMR) sensors (HMC5883L).
Deng Gong, Lunwu Zhao, Gang Han
doaj +1 more source
Nigerian Journal of Technological Development, 2021 Aluminium Silicon Carbide (AlSiC) composite materials are used in the electronics industries and other manufacturing companies hence, manufacturing of AlSiC composite materials with the right properties for different applications are vital to most ...
Mathias Ekpu
doaj
Microstructure-based model for the stress-strain relationship of hot-rolled dual-phase steel
工程科学学报, 2015 The microstructure of hot-rolled dual-phase steel was studied by scanning electron microscopy(SEM) and transmission electron microscopy(TEM). The volume fraction of each phase in the dual-phase steel was determined by Image-Pro Plus software.
PANG Qi-hang, TANG Di, ZHAO Zheng-zhi
doaj +1 more source
FEBS Open Bio, EarlyView.We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado +4 more
wiley +1 more source
Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins
FEBS Open Bio, EarlyView.We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó +7 more
wiley +1 more source
The Effects of Locomotion-Induced Shock Loading on Tibiofemoral Bone Stress Response
, 2016 Purpose/Hypothesis: Knee osteoarthritis (Coats, Zioupos, & Aspden) is a degenerative joint disease that negatively impacts the quality of life. About 9.3 million people in the U.S. population are affected.
Daun, Karen +2 more
core +1 more source
The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells
FEBS Open Bio, EarlyView.We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel +8 more
wiley +1 more source