Results 41 to 50 of about 1,221,683 (286)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Research On A Novel Method For VRF Tooth Preservation

International Dental Journal
Aim or purpose: Propose a novel therapeutic approach for verticall root fractured (VRF)tooth preservation, with fracture resistance evaluation via Finite element analysis(FEA) and ex vivo mechanical testing. Materials and methods: 1.
Chen Yiting, Zhang Haiying, Hou Benxiang
doaj   +1 more source

Stress Testing Method for Scenario-Based Testing of Automated Driving Systems

IEEE Access, 2020
Classical approaches for testing of automated driving systems (ADS) of SAE levels 1 and 2 were based on defined scenarios with specific maneuvers, depending on the function under test.
Demin Nalic, Hexuan Li, Arno Eichberger, Christoph Wellershaus, Aleksa Pandurevic, Branko Rogic   +5 more
doaj   +1 more source

Hippocampal structural plasticity accompanies the resulting contextual fear memory following stress and fear conditioning [PDF]

, 2013
The present research investigated the resulting contextual fear memory and structural plasticity changes in the dorsal hippocampus (DH) following stress and fear conditioning. This combination enhanced fear retention and increased the number of total and
Calfa, Gaston Diego, Giachero, Marcelo, Molina, Víctor Alejandro   +2 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Characterization of Alaskan Hot-Mix Asphalt containing Reclaimed Asphalt Pavement Material [PDF]

, 2016
In order to properly characterize Alaskan HMA materials containing RAP, this study evaluated properties of 3 asphalt binders typically used in Alaska, PG 52-28, PG 52-40, and PG 58-34, and 11 HMA mixtures containing up to 35% RAP that were either ...
Li, Lin, Liu, Jenny, Zhao, Sheng
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Effect of Zirconia Thickness on the Tensile Stress of Zirconia Based All-Ceramic Restorations [PDF]

Journal of Dental Materials and Techniques, 2015
Introduction: The purpose of the presented study was to evaluate the effect of zirconia thickness on the tensile stress of zirconia based all-ceramic restorations.
Masood Shiezadeh, Mahdie Seyf, Hamid Reza Rajati, Asadolah Karazhian, Pouria Mohammadparast   +4 more
doaj   +3 more sources

Fuzzy multicomponent stress-strength reliability in presence of partially accelerated life testing under generalized progressive hybrid censoring scheme subject to inverse Weibull model

MethodsX
It typically takes a lot of time to monitor life-testing experiments on a product or material. Units can be tested under harsher conditions than usual, known as accelerated life tests to shorten the testing period. This study's goal is to investigate the
Neama Salah Youssef Temraz
doaj   +1 more source