Results 51 to 60 of about 1,221,683 (286)

Experimental Measurement Method for Contact Stress of Elastic Metal Sealing Ring Based on Pressure Sensitive Paper

Metals, 2018
As a basic mechanical component, the sealing ring is widely used in industrial, aerospatial, and other fields. In this study, an elastic metal C-shaped sealing ring with a wave structure was taken as an example, and its performance was analyzed ...
Miaotian Zhang, Shuangfu Suo, Yang Jiang, Guoying Meng   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Comparative Analysis of RESTful, GraphQL, and gRPC APIs: Perfomance Insight from Load and Stress Testing

Jurnal Sisfokom
Backend constitutes a critical component of digital infrastructure, responsible for processing business logic, managing data, and facilitating communication between software systems. APIs serve as the interface that enables software interaction and plays
Steven Chandra, Ahmad Farisi
doaj   +3 more sources

Faculty and Student Perceptions of Academic Integrity in Technology-Assisted Learning and Testing

Frontiers in Education, 2021
The recent COVID-19 pandemic presented challenges to faculty (Fac) and students (Stu) to uphold academic integrity when many classes transitioned from traditional to remote.
Helaine Mary Alessio, Jeff D. Messinger
doaj   +1 more source

The performance and prediction ability of advanced approach to ductile fracture [PDF]

, 2017
The present paper deals with the modelling of ductile fracture which is the result of severe plastic deformation under monotonic loading. It can be the result of a crash or accident or introduced intentionally. There is a need of increasing the safety in
Kubik, Petr, Petruska, Jindrich, Sêbek, Frantisek   +2 more
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Stress Analysis of Meshing Gear with Staggering Tooth

Jixie chuandong, 2015
The contact stress and bending stress are calculated and comparatively analyzed with the same meshing tooth width by using three methods of the national standard formula based,Romax software（full tooth meshing） and Romax software（staggering tooth meshing）
Liu Yaqiong, Wang Tie, Wu Zhifei, Zhang Ruiliang, Shi Ruonan, Wu Ping’an   +5 more
doaj  

SNIFFER WFD119: Enhancement of the River Invertebrate Classification Tool (RICT) [PDF]

, 2011
EXECUTIVE SUMMARY Project funders/partners: Environment Agency (EA), Northern Ireland Environment Agency (NIEA), Scotland & Northern Ireland Forum for Environmental Research (SNIFFER), Scottish Environment Protection Agency (SEPA) Background to ...
Clarke, Ralph T., Davy-Bowker, John, Dunbar, M., Laize, C., Murphy, J.F., Scarlett, P.M.   +5 more
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source