Results 61 to 70 of about 2,376,179 (319)

Experimental Measurement Method for Contact Stress of Elastic Metal Sealing Ring Based on Pressure Sensitive Paper

Metals, 2018
As a basic mechanical component, the sealing ring is widely used in industrial, aerospatial, and other fields. In this study, an elastic metal C-shaped sealing ring with a wave structure was taken as an example, and its performance was analyzed ...
Miaotian Zhang, Shuangfu Suo, Yang Jiang, Guoying Meng   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Integrated structural analysis tool using linear matching method part 1 : Software development [PDF]

, 2014
A number of direct methods based upon the Linear Matching Method (LMM) framework have been developed to address structural integrity issues for components subjected to cyclic thermal and mechanical load conditions.
Chen, Haofeng, Tipping, David, Ure, James   +2 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Comparative Analysis of RESTful, GraphQL, and gRPC APIs: Perfomance Insight from Load and Stress Testing

Jurnal Sisfokom
Backend constitutes a critical component of digital infrastructure, responsible for processing business logic, managing data, and facilitating communication between software systems. APIs serve as the interface that enables software interaction and plays
Steven Chandra, Ahmad Farisi
doaj   +3 more sources

Faculty and Student Perceptions of Academic Integrity in Technology-Assisted Learning and Testing

Frontiers in Education, 2021
The recent COVID-19 pandemic presented challenges to faculty (Fac) and students (Stu) to uphold academic integrity when many classes transitioned from traditional to remote.
Helaine Mary Alessio, Jeff D. Messinger
doaj   +1 more source

The performance and prediction ability of advanced approach to ductile fracture [PDF]

, 2017
The present paper deals with the modelling of ductile fracture which is the result of severe plastic deformation under monotonic loading. It can be the result of a crash or accident or introduced intentionally. There is a need of increasing the safety in
Kubik, Petr, Petruska, Jindrich, Sêbek, Frantisek   +2 more
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Towards the Assessment of Stress and Emotional Responses of a Salutogenesis-Enhanced Software Tool Using Psychophysiological Measurements [PDF]

International Workshop on Emotion Awareness in Software Engineering, 2017
Software development is intellectual, based on collaboration, and performed in a highly demanding economic market. As such, it is dominated by time pressure, stress, and emotional trauma.
Jan-Peter Ostberg, D. Graziotin, S. Wagner, B. Derntl   +3 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source