Results 81 to 90 of about 1,221,683 (286)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

A Magnetotelluric Signal Acquisition and Monitoring System Based on a Cloud Platform

open access: yesApplied Sciences
This study designed and implemented an magnetotelluric signal acquisition and monitoring system (CMT) based on an Internet of Things (IoT) cloud platform.
Qi Luo   +4 more
doaj   +1 more source

DETERMINATION OF THE BASIC PARAMETERS OF SENSOR DEVICES FOR THE IMPLEMENTATION OF PSYCHONEUROLOGICAL RESEARCH WITH THE INTRODUCTION OF MULTITOUCH TECHNOLOGY

open access: yesСучасний стан наукових досліджень та технологій в промисловості, 2020
The subject of the article is the testing process on multi-touch devices for the implementation of psychoneurological studies. The goal of the work is development specialized dynamic tests with the introduction of Multi-touch technology to detect carpal ...
Karina Selivanova   +2 more
doaj   +1 more source

Development and evaluation of a fault-tolerant multiprocessor (FTMP) computer. Volume 4: FTMP executive summary [PDF]

open access: yes
The FTMP architecture is a high reliability computer concept modeled after a homogeneous multiprocessor architecture. Elements of the FTMP are operated in tight synchronism with one another and hardware fault-detection and fault-masking is provided which
Lala, J. H., Smith, T. B., III
core   +1 more source

Integrated structural analysis tool using linear matching method part 1 : Software development [PDF]

open access: yes, 2014
A number of direct methods based upon the Linear Matching Method (LMM) framework have been developed to address structural integrity issues for components subjected to cyclic thermal and mechanical load conditions.
Chen, Haofeng   +2 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

System reliability and risk assessment task goals and status [PDF]

open access: yes
The major focus for continued development of the Numerical Evaluation of Stochastic Structures Under Stress (NESSUS) codes is in support of system testing and certification of advanced propulsion systems.
Cruse, T. A., Mahadevan, S.
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

J2EE application for clustered servers : focus on balancing workloads among clustered servers : a thesis presented in partial fulfilment of the requirements for the degree of Master of Information Science in Computer Science at Massey University, Albany, New Zealand [PDF]

open access: yes, 2006
J2EE has become a de facto platform for developing enterprise applications not only by its standard based methodology but also by reducing the cost and complexity of developing multi-tier enterprise applications.
Chen, Xi
core  

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