Results 131 to 140 of about 2,718,585 (285)

Stress or strain? [PDF]

This article is intended to reconcile the stress-based and strain-based formulations for material failure criteria, where a long-standing and deep division is present.
Li, Shuguang
core   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

The Theory of Set Tolerances

, 2014
The theory of single upper and lower tolerances for combinatorial minimization problems has been formalized in 2005 for the three types of cost functions sum, product and maximum, and since then shown to be rather useful in creating heuristics and exact ...
Pardalos, Panos M.,, Jäger, Gerold,, Gerold Jäger, Boris Goldengorin, Panos M. Pardalos, Goldengorin, Boris,   +5 more
core   +1 more source

Modulating TPP riboswitch activity simultaneously enhances crop yield, nutritional quality and stress tolerance

Nature Communications
While enhancing crop yield remains a critical breeding objective, such efforts often compromise nutritional quality and stress tolerance. The growing global population and increasing environmental stresses make combining stable crop yields with improved ...
Yufei Li, Kang Li, Jiazhi Lu, Mustafa Bulut, Huanteng Hou, Qamar U. Zaman, Ran Zhang, Zhuang Yang, Chenkun Yang, Chuansong Zhan, Guan Wang, Tong Chen, Xianqing Liu, Qiao Zhao, Shuangqian Shen, Alisdair R. Fernie, Jie Luo   +16 more
doaj   +1 more source

Improving component dimensional accuracy in electron beam powder bed fusion by addressing nonlinear deformations with 3D compensation strategies

Virtual and Physical Prototyping
Electron beam powder bed fusion (EB-PBF) is effective for producing complex geometrical components with minimal residual stress because of elevated powder bed temperatures; however, it faces challenges in achieving dimensional accuracy due to nonlinear ...
Chen Wang, Chen-Nan Sun, Lei Zhang, Stefanie Feih, Pan Wang   +4 more
doaj   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

Cadmium stress effects indicating marine pollution in different species of sea urchin employed as environmental bioindicators

, 2019
In recent years, researches about the defense strategies induced by cadmium stress have greatly increased, invading several fields of scientific research.
Martino C., Roccheri M. C., Chiarelli R.
core   +1 more source

A Return to Normality: A Descriptive Qualitative Interview Study Exploring the Patient Experience of Gout Flare Resolution

Arthritis Care &Research, EarlyView.
Objective Although the definition of a gout flare is well established, the state of gout flare resolution has not yet been defined. This study aimed to explore patients’ experiences and perceptions of gout flare resolution. Methods Semistructured interviews were conducted with 24 people with gout, guided by open‐ended questions exploring their ...
Sarah Stewart, Anne Horne, Angelo Gaffo, Lisa K. Stamp, N. Lawrence Edwards, Nicola Dalbeth   +5 more
wiley   +1 more source

Microvascular Damage Is Associated With Carotid Wall Structural Changes in Systemic Sclerosis: A Capillaroscopy and Ultrasound‐Based Observational Study

Arthritis Care &Research, EarlyView.
Objective Systemic sclerosis (SSc) is characterized by cardiovascular risk excess not fully explained by traditional factors. Whether the severity of microvascular damage correlates with structural subclinical atherosclerosis remains unclear. We investigated the relationship between nailfold videocapillaroscopy (NVC) abnormalities and carotid ...
Eugenio Capparelli, Luca Clerici, Francesco Lapia, Giusy C. Moltisanti, Eleonora Zaccara, Greta Pellegrino, Daniela Bompane, Francesca Capelli, Letizia Ferrami, Laura Castelnovo, Antonio Tamburello, Maria Sole Chimenti, Paola Faggioli, Antonino Mazzone   +13 more
wiley   +1 more source