Results 151 to 160 of about 747,930 (316)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2019 This work presents a novel mathematical model for the analysis of thermal stresses in a radiative annular fin with temperature-dependent thermal conductivity and radiative parameter.
Prasad, Dilip Kumar +2 more
core +1 more source
Unveiling unique metabolomic and transcriptomic profiles in three Brassicaceae crops
Frontiers in Plant ScienceBrassica napus, Camelina sativa and field pennycress (Thlaspi arvense), represent one highly economically valuable crop and two emerging oilseed crops of the Brassicaceae family, respectively. As sessile organisms, these crops are continuously exposed to
Liyong Zhang, Isobel A. P. Parkin
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Measurement and modelling of the transient thermal-mechanical strain field during GMA welding [PDF]
, 2011 The state of residual stress in welded joints is a well-studied topic, and many methodsof residual stress measurement are now available. However, far less is known aboutthe transient strains which occur during the welding process, even though these ...
Colegrove, Paul A. +3 more
core
Residual Stresses in a Nickel-based Superalloy Introduced by Turning
, 2002 Near-surface residual stress distributions in the nickel-based superalloy Inconel 718 that originate from the machining operation turning are studied.
Peng, Ru, +4 more
core +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source