Results 141 to 150 of about 747,930 (316)
, 2014 The ratchet boundaries and ratchet strains are derived for the Bree problem and an elastic perfectly plastic material with different yield stresses on-load and off-load.
Chen, Haofeng +2 more
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Fluorescence microscopy investigation on residual stresses in alumina-based ceramics
, 2008 Grinding/polishing and indentation induced residual stresses were measured by confocal Cr3+ fluorescence microscopy with high spatial resolution (~2 μm),obtaining local stress variation information rather than the mean stress averaged over a large ...
Guo, Sheng
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2009 Fatigue cracks in welds often occur at the toe of a weld where stresses are difficult to calculate at the design stage. To circumvent this problem the ASME Boiler and PV code Section VIII Division 2 Part 5 [1] uses the structural stress normal to the ...
Degiorgio, Kevin +5 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
STRESSES AND DEFORMABILITY OF ROCK MASS UPON OPEN PIT EXPLOITATION OF DIMENSION STONE
Rudarsko-geološko-naftni Zbornik, 2003 The appearance of increased stresses and deformability of rock mass in the quarry of Zečevo (exploitation field of Selca – island of Brač) has caused a considerable decrease of usability of mineral raw materials, which put into question the survival of ...
Siniša Dunda +2 more
doaj
Structural static and modal frequency simulations in a coffee harvester’s chassis
Revista Brasileira de Engenharia Agrícola e AmbientalCoffee harvesters are subject to stresses and vibrations in their structure, originating from engines and harvesting system. These structures must be designed to avoid rupturing of the components due to fragility of the materials, inadequate geometries ...
Evandro P. da Silva +3 more
doaj +1 more source