Results 121 to 130 of about 747,930 (316)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Analysis of the effect of bending, fatigue, erosion-corrosion and tensile stresses on HVOF coating of metallic surfaces [PDF]
, 2006 The aim of the present study was to evaluate the bending, fatigue, tensile stresses and erosion-coiTosion characteristics o f HVOF thermally sprayed Inconel-625 powder coatings when deposited on three different metallic surfaces: (a) plain stainless ...
Al Fadhli, Hussain
core
FINITE ELEMENT MODELING OF RUTTING FOR FLEXIBLE PAVEMENT
Journal of Engineering and Sustainable Development, 2018 The aim of this research is studying the effect of base and subgrade layer local materials properties on the rutting damage of flexible pavement due to repeated traffic loading. The most roads in Baghdad city present severe rutting damage due to absence
Zainab Ahmed Alkaissi +1 more
doaj
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Residual stresses and deformations in a welded thin-walled pipe
, 1989 Deformations and stresses during butt-welding of a pipe are calculated as well as the residual deformations and stresses. The temperature field during welding is calculated using an analytical solution. The deformations and stresses are calculated by use
Näsström, Mats, +4 more
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Stresses Calculation of Sliding Friction Surfaces
Stresses Calculation of Sliding Friction ...
Torims, Toms +3 more
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source