Results 91 to 100 of about 1,522,607 (355)
The Effect of Chronic Stress on Generalization of Conditioned Fear [PDF]
, 2016 Prior lifetime experience of stress is a significant risk factor for posttraumatic stress disorder (PTSD) and other anxiety disorders. The mechanisms by which stress conveys these effects are unknown and likely involve complicated neurobiological ...
Senatore, Amanda J
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Perceived Stress Among Chinese Medical Students Engaging in Online Learning in Light of COVID-19
Psychology Research and Behavior Management, 2021 Jun Wang,1,* Weichu Liu,2,* Yunmei Zhang,3 Shiqi Xie,3 Bing Yang4 1Department of Nursing, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Gynecology, The First Affiliated Hospital
Wang J, Liu W, Zhang Y, Xie S, Yang B
doaj
Novelty Induces Behavioural And Glucocorticoid Responses In A Songbird Artificially Selected For Divergent Personalities [PDF]
, 2017 Stress physiology is thought to contribute to individual differences in behaviour. In part this reflects the fact that canonical personality measures consist of responses to challenges, including novel objects and environments.
Baugh, Alexander T. +5 more
core +2 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Animal, 2016 It is known that tactile stimulation (TS) during ontogeny modifies brain plasticity and enhances the motor and cognitive skills. Our hypothesis was that early handling including TS would increase play and exploratory behaviour in commercial pigs under ...
M. Zupan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source