Results 161 to 170 of about 5,188,883 (353)

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Stress Factors of the Urban Digital Environment: Personal Determinants of Susceptibility

Национальный психологический журнал
Background. Modern digital urban environment, as a representation of real urban environment, functions according to the rules of living environment, including its being a real source of stress.
Olga V. Kruzhkova, Irina V. Vorobyeva, Alena I. Matveeva, Natalia E. Zhdanova   +3 more
doaj   +1 more source

Effect of Stress Amplitude on Statistical Variability in Fatigue Life of 75S-T6 Aluminum Alloy [PDF]

, 1953
G.M. Sinclair, Thomas J. Dolan
openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

STUDIES ON THE INTERDEPENDENT EFFECTS OF STRESS AND THE ADRENAL CORTEX ON CARBOHYDRATE METABOLISM IN MAN 1 [PDF]

, 1953
Thomas W. Burns, Frank L. Engel, Alberto Viau, James Scott, Dorothy R. Hollingsworth, Emile E. Werk, Evangeline Robertson   +6 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Thermodynamics of solids under non-hydrostatic stress with geologic applications [PDF]

, 1957
Gordon J. F. MacDonald
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Thermal Stresses in Elastic Plates

, 1939
I. S. Sokolnikoff, E. S. Sokolnikoff
openalex   +1 more source

Stress-Strain Relations in Snow under Uniaxial Compression [PDF]

, 1955
Joseph K. Landauer
openalex   +1 more source