Results 81 to 90 of about 1,522,607 (355)

Effect of vasopressin 1b receptor blockade on the hypothalamic-pituitary-adrenal response of chronically stressed rats to a heterotypic stressor [PDF]

, 2009
Exposure to chronic restraint (CR) modifies the hypothalamic–pituitary–adrenal (HPA) axis response to subsequent acute stressors with adaptation of the response to a homotypic and sensitization of the response to a heterotypic stressor. Since vasopressin
Craighead, Mark, Harrison, Louise R., Lightman, Stafford L., MacSweeney, Cliona P., Spiga, Francesca, Thomson, Fiona J.   +5 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Protein changes as robust signatures of fish chronic stress: a proteomics approach to fish welfare research [PDF]

, 2020
Background Aquaculture is a fast-growing industry and therefore welfare and environmental impact have become of utmost importance. Preventing stress associated to common aquaculture practices and optimizing the fish stress response by ...
Cerqueira, Marco, Farinha, Ana Paula, Kuehn, Annette, Planchon, Sébastien, Raposo de Magalhães, Cláudia, Revets, Dominique, Rodrigues, Pedro, Schrama, Denise   +7 more
core  

Demographic variables, clinical aspects, and medicolegal implications in a population of patients with adjustment disorder [PDF]

, 2016
INTRODUCTION: Although adjustment disorder (AD) is considered as residual diagnosis and receives little attention in research, it plays an important role in clinical practice and also assumes an increasingly important role in the field of legal medicine,
Anastasia, Annalisa, Bersani, Giuseppe, Colletti, Chiara, Cuoco, Valentina, Quartini, Adele, Rinaldi, Raffaella, Urso, Stefania   +6 more
core   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Assessment of Stress in Medical Emergency Staff in Ardabil Province, Iran

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2014
Background and Objectives: Occupational stress is a chronic disease, which is caused by harsh working conditions, and affects individual performance and physical and mental health. This study aimed to determine the level of occupational stress in medical
Mehri Seyedjavadi, Nasrin Samadi, Raheleh Mohammadi, Ali Osmani, Fariba Bakhtiari Kohsareh, Maryam Seyedjavadi   +5 more
doaj  

Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers [PDF]

, 2017
There is a complex bidirectional relationship between stress and epilepsy. Stressful stimuli and subsequent cortisol release act as a trigger for seizure activity in some individuals with epilepsy, and seizure activity itself may act as a stressor to the
Fowkes, R C, Packer, R M A, Volk, H A
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Occupational history of psychosocial work environment exposures and risk of autoimmune rheumatic diseases – a Danish register-based cohort study

Scandinavian Journal of Work, Environment & Health
OBJECTIVES: This population-based cohort study examined the association between psychosocial work environment exposures and autoimmune rheumatic diseases, including rheumatoid arthritis (RA), systemic sclerosis (SS), and systemic lupus erythematosus (SLE)
Helena Breth Nielsen, Camilla Sandal Sejbaek, Lene Wohlfahrt Dreyer, Ida EH Madsen, Esben Meulengracht Flachs, Karin Sørig Hougaard   +5 more
doaj   +1 more source