Results 81 to 90 of about 789,824 (307)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
The long-term effects of consecutive COVID-19 waves on mental health
BJPsych OpenBackground Although several studies have documented the impact of the COVID-19 pandemic on mental health, the long-term effects remain unclear. Aims To examine longitudinal changes in mental health before and during the consecutive COVID-19 waves in a ...
Jan Sebastian Novotný +10 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Stress Level and Coping Strategies Among Nursing Students Engaged in Student Union [PDF]
, 2015 Extracurricular activities or student union is a means for students to develop their interests, talents, and potentials. Student involvement in the student union can cause stress such as pressure to accomplish tasks and responsibilities within the ...
Mu'in, Muhammad, Pratiwi, Nunun
core
Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Psychosocial work and home stressors predict sickness absence from work [PDF]
, 2010 info:eu-repo/semantics ...
Braeckman, Lutgart +6 more
core +1 more source
Simulation, a tool for designing-in reliability [PDF]
, 1993 This paper describes a new method for the analysis and optimization of reliability as an integrated part of the design process of electronic circuits. It bases itself on the analysis of the susceptibility of failure mechanisms in components as a function
Arendsen, Robert +4 more
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
An investigation of occupational stress in New Zealand dentists : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University [PDF]
, 1995 The present study sought to identify the occupational stressors as well as the resultant psychological and physical stress outcomes for New Zealand dentists.
Bate, Colin
core
Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source