Results 101 to 110 of about 143,804 (311)

An inventory of mammals, birds and reptiles along a section of the river and banks of upper Ganges, India

open access: yesJournal of Threatened Taxa, 2012
A study was conducted to assess faunal diversity along a 165-km stretch of the upper Ganges River between Bijnor and Narora cities, Uttar Pradesh, from January to June 2007.
T. Bashir   +3 more
doaj   +1 more source

The Effect of Stretching on the Rate of Conduction in the Neuro-Muscular Network in Cassiopea [PDF]

open access: yesProceedings of the National Academy of Sciences, 1917
It was observed by Carlson (Amer. J. Physiol., 27, 1911, 323) that stretching the nerve of the slug has no effect on the rate of the nerve impulse. This does not support Bethe's hypothesis that the impulse passes over solid neuro-fibrillae which are zig-zagged in the relaxed nerve and straightened out in the stretched nerve.
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Effects of oxidation in the power of chemically skinned rat soleus fibres [PDF]

open access: yes, 2010
Oxidation alters calcium sensitivity, and decreases maximum isometric force (Po) and shortening velocity (Vmax) of single muscle fibres. To examine the effect of oxidation on the curvature of the force-velocity relationship, which determines muscle power
Rittweger, Jörn   +3 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Effects of Mechanical Stretch on Collagen and Cross-Linking in Engineered Blood Vessels

open access: yesCell Transplantation, 2009
It has been shown that mechanical stimulation affects the physical properties of multiple types of engineered tissues. However, the optimum regimen for applying cyclic radial stretch to engineered arteries is not well understood.
Amy Solan   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Coherent laser source for high frame-rate optical time-stretch microscopy at 1.0 μm [PDF]

open access: yes, 2014
We demonstrate a coherent picosecond pulsed fiber laser for the high frame-rate optical time-stretch microscopy at 1.0 μm. The spectrum of a picosecond pulsed laser is commonly broadened before the time-stretch imaging, which however will degrade its ...
Wei, Xiaoming   +11 more
core   +1 more source

Cardiac myosin binding protein-C phosphorylation modulates myofilament length-dependent activation

open access: yesFrontiers in Physiology, 2016
Cardiac myosin binding protein-C (cMyBP-C) phosphorylation is an important regulator of contractile function, however, its contributions to length-dependent (SL) changes in cross-bridge (XB) kinetics is unknown.
Ranganath eMamidi   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

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