Results 131 to 140 of about 13,470,362 (342)
Stability of a premixed flame in stagnation-point flow against general disturbances [PDF]
Previously, the stability of a premixed flame in a stagnation flow was discussed for a restricted class of disturbances that are self-similar to the basic undisturbed flow; thus, flame fronts with corrugations only in the cross stream direction were ...
Jackson, Thomas L., Matalon, Moshe
core +1 more source
Flame interactions in turbulent premixed twin V-flames [PDF]
, 2013 Multiple flame-flame interactions in premixed combustion are investigated using Direct Numerical Simulations of twin turbulent V-flames for a range of turbulence intensities and length scales.
Bray, KNC +3 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Slow and fast motion of cracks in inelastic solids. Part 1: Slow growth of cracks in a rate sensitive tresca solid. Part 2: Dynamic crack represented by the Dugdale model [PDF]
An extension is proposed of the classical theory of fracture to viscoelastic and elastic-plastic materials in which the plasticity effects are confined to a narrow band encompassing the crack front.
Sih, G. C., Wnuk, M. P.
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Widespread depolarization during expiration: A source of respiratory drive? [PDF]
, 2014 Respiration influences various pacemakers and rhythms of the body during inspiration and expiration but the underlying mechanisms are relatively unknown.
Barnes, Vernon A. +3 more
core
The Stretch - Length Tradeoff in Geometric Networks: Average Case and Worst Case Study
, 2014 Consider a network linking the points of a rate-$1$ Poisson point process on the plane. Write $\Psi^{\mbox{ave}}(s)$ for the minimum possible mean length per unit area of such a network, subject to the constraint that the route-length between every pair ...
Aldous, David, Lando, Tamar
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source