Results 161 to 170 of about 16,176 (251)

Expanded characterization of the valproic acid zebrafish larval model of autism spectrum disorder: Insights into dysregulation in the gut

Animal Models and Experimental Medicine, EarlyView.
Meticulous calculation of zebrafish‐equivalent therapeutic valproic acid (VPA) dosage maximized the translational value of the data. Hyposerotonergic tone underpinned an anxiety‐like outcome as a core symptom of autism spectrum disorder (ASD). Compartment‐specific dopaminergic and serotonergic dysregulation in the brain versus gut provided mechanistic ...
Lesha Pretorius, Johanna Adriana Coetzee, Alexio Pedro dos Santos, Carine Smith   +3 more
wiley   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Integrating machine learning, deep learning, and image analysis for seed species classification

Applications in Plant Sciences, EarlyView.
Abstract Premise The growing demand for wildflower seeds in ecological restoration requires reliable species identification, yet current market products often contain heterogeneous species. As seed identification is labor‐intensive and requires advanced botanical knowledge, we evaluated multiple segmentation and classification approaches to determine ...
Jonathan Ashworth, Eloise Barrett, Rebonto Haque, Ben Wildey, Anthony Hall, Felix Shaw, Jose J. De Vega   +6 more
wiley   +1 more source

Ontogeny of murine bony semicircular canal form

The Anatomical Record, EarlyView.
Abstract The labyrinthine geometry and functional anatomy of the semicircular canals have intrigued scientists for decades, and there has been considerable interest in understanding how these complex structures grow and develop with evidence emerging from human studies that size maturation occurs exceptionally early by comparison with other systems ...
Marcela Cárdenas‐Serna, Nathan Jeffery   +1 more
wiley   +1 more source

Stretch-Induced Muscle Responses Under Threat Versus Safety. [PDF]

Eur J Neurosci
Visser YF, Bramson B, Medendorp WP, Roelofs K, Selen LPJ.   +4 more
europepmc   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

5-HT_1D receptors inhibit the monosynaptic stretch reflex by modulating C-fiber activity.

J Neurophysiol, 2019
Lucas-Osma AM, Li Y, Murray K, Lin S, Black S, Stephens MJ, Ahn AH, Heckman CJ, Fenrich KK, Fouad K, Bennett DJ.   +10 more
europepmc   +1 more source

Innervation of the tubarial glands: A hypothesis‐driven anatomical review

The Anatomical Record, EarlyView.
Abstract The tubarial glands have been described as a macroscopic bilateral glandular complex in the posterolateral nasopharynx near the torus tubarius and the pharyngeal opening of the Eustachian tube. Since their recognition on prostate‐specific membrane antigen‐based imaging, their anatomical classification has remained debated, with converging ...
Mugurel Constantin Rusu, Ivan Varga, Răzvan Costin Tudose   +2 more
wiley   +1 more source

A biomimetic ducted nipple reveals gestational age‐dependent deficits in suction generation in a neonatal pig model

The Anatomical Record, EarlyView.
Abstract All infant mammals must suckle in order to effectively acquire milk from a nipple. Yet, not all infants are able to do so. Preterm infants in particular face significant feeding challenges, often failing to establish successful breastfeeding due to complex neurophysiologic challenges.
Max Sarmet, Emily C. Volpe, Elska B. Kaczmarek, Maressa E. Kennedy, Ani E. Smith, Hannah E. Shideler, Harlow I. Smith, Dylan J. Anderson, Thomas H. Stroud, Christopher J. Mayerl   +9 more
wiley   +1 more source

From Neurophysiological Mechanisms to Rehabilitation After Botulinum Toxin Type A in Post-Stroke Spasticity. [PDF]

Toxins (Basel)
Eeckhaut B, Truijen S, Haghshenas P, Roussou A, Taflampas P, Saeys W.   +5 more
europepmc   +1 more source