Results 241 to 250 of about 192,251 (301)

Potentiation effects of the positive allosteric modulator PTC‐174 on NMDA receptors in neonatal male rat substantia nigra dopaminergic neurons

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Morphology‐based phylogeny of longhorn beetles (Coleoptera, Cerambycidae) aligns with phylogenomics and informs higher‐level systematics

open access: yesCladistics, EarlyView.
Abstract We present a morphology‐based backbone phylogeny of Cerambycidae beetles inferred by parsimony analyses using 77 adult characters scored for 101 species. This phylogeny is largely consistent with recent phylogenomic studies regarding key placements (e.g., Parandrini stat. rev. within Prioninae, Necydalini stat. rev.
Burcu Şabanoğlu Şimşek   +2 more
wiley   +1 more source

PIWIL2 drives stroke progression via modulation of NF-κB signaling. [PDF]

open access: yesMol Ther Nucleic Acids
Patil RM   +11 more
europepmc   +1 more source

Calbindin stratifies midbrain dopaminergic neurons governing distinct aspects of locomotion. [PDF]

open access: yesProc Natl Acad Sci U S A
Bolduc C   +12 more
europepmc   +1 more source

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