Results 131 to 140 of about 1,593 (170)

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Vocal features based Parkinson's detection: An ensemble learning approach. [PDF]

MethodsX
Chakole M, Dorle S, Agrawal R, Dasarwar P, Yadav U, Sharma R.   +5 more
europepmc   +1 more source

CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction

Advanced Science, EarlyView.
CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su, Xitao Wang, Musen Li, Guanhua Qin, Shunbo Hu, Tong‐Yi Zhang   +5 more
wiley   +1 more source

Domain adaptation, self-supervision, and generative augmentation enhance GNNs for breast cancer prediction. [PDF]

Sci Rep
Qiu S, Zhao Y, Li X.
europepmc   +1 more source

Data‐Driven Discovery of Unconventional Antiferromagnets

Advanced Science, EarlyView.
A high‐throughput workflow that combines the physics‐informed pre‐screening, high‐throughput exchange calculations, Luttinger‐Tisza analysis and symmetry classification is established for accurate identification of unconventional antiferromagnets from the broad structural database.
Qirui Cui, Chenxu Liu, Anna Delin, Kaiyou Wang   +3 more
wiley   +1 more source

Enhanced early detection of thyroid cancer using ensemble machine learning and serum proteomics. [PDF]

Front Oncol
Zhang D, Ding J, Zhou Z.
europepmc   +1 more source

Interfacial Water Configurations: Evolution and Implications for Electrocatalysis

Advanced Science, EarlyView.
A comprehensive and mechanistic understanding of how interfacial water structures govern reaction pathways. This review aims to bridge the gap between unraveling the intricate role of water structures and establishing robust design principles for advanced catalysts.
Aoqi Wang, Yang Song, Lin Guo, Chenchen Weng, Yanxia Yuan, Chaoyu Li, Xue Yang, Wei Lin   +7 more
wiley   +1 more source

Genetic structure analysis of a Northwest Chinese population using a self-developed DIP system and machine learning for forensic ancestry inference. [PDF]

BMC Genomics
Cai M, Shen R, Shi X, Wu Y, Luo L, Liang Q, Zhu B.   +6 more
europepmc   +1 more source

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source

Robust integration and annotation of single-cell and spatial omics data using interpretable gene programs. [PDF]

Cell Genom
Zhang Y, Ming W, Yu B, Wang L, Lu K, Xu L, Ni Y, Deng R, Chen D.   +8 more
europepmc   +1 more source