Results 31 to 40 of about 7,158 (237)

Inertial Measurement Unit-Based Estimation of Foot Trajectory for Clinical Gait Analysis

Frontiers in Physiology, 2020
Gait analysis is used widely in clinical practice to evaluate abnormal gait caused by disease. Conventionally, medical professionals use motion capture systems or make visual observations to evaluate a patient's gait.
Koyu Hori, Yufeng Mao, Yumi Ono, Hiroki Ora, Yuki Hirobe, Hiroyuki Sawada, Akira Inaba, Satoshi Orimo, Yoshihiro Miyake   +8 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Markerless Stride Length estimation in Athletic using Pose Estimation with monocular vision

CoRR
Performance measures such as stride length in athletics and the pace of runners can be estimated using different tricks such as measuring the number of steps divided by the running length or helping with markers printed on the track. Monitoring individual performance is essential for supporting staff coaches in establishing a proper training schedule ...
Patryk Skorupski, Cosimo Distante, Pier Luigi Mazzeo   +2 more
openaire   +2 more sources

A multi-sensor wearable system for the assessment of diseased gait in real-world conditions

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Accurately assessing people’s gait, especially in real-world conditions and in case of impaired mobility, is still a challenge due to intrinsic and extrinsic factors resulting in gait complexity.
Francesca Salis, Francesca Salis, Stefano Bertuletti, Stefano Bertuletti, Tecla Bonci, Marco Caruso, Marco Caruso, Kirsty Scott, Lisa Alcock, Lisa Alcock, Ellen Buckley, Eran Gazit, Clint Hansen, Lars Schwickert, Kamiar Aminian, Clemens Becker, Philip Brown, Anne-Elie Carsin, Anne-Elie Carsin, Anne-Elie Carsin, Brian Caulfield, Lorenzo Chiari, Lorenzo Chiari, Ilaria D’Ascanio, Silvia Del Din, Silvia Del Din, Bjoern M. Eskofier, Judith Garcia-Aymerich, Judith Garcia-Aymerich, Judith Garcia-Aymerich, Jeffrey M. Hausdorff, Emily C. Hume, Cameron Kirk, Felix Kluge, Felix Kluge, Sarah Koch, Sarah Koch, Sarah Koch, Arne Kuederle, Walter Maetzler, Encarna M. Micó-Amigo, Arne Mueller, Isabel Neatrour, Anisoara Paraschiv-Ionescu, Luca Palmerini, Luca Palmerini, Alison J. Yarnall, Alison J. Yarnall, Alison J. Yarnall, Lynn Rochester, Lynn Rochester, Lynn Rochester, Basil Sharrack, David Singleton, Beatrix Vereijken, Ioannis Vogiatzis, Ugo Della Croce, Ugo Della Croce, Claudia Mazzà, Andrea Cereatti, Andrea Cereatti, for the Mobilise-D consortium   +61 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

GenReGait: Gender Recognition using Gait Features

Journal of Informatics and Web Engineering, 2023
Gender recognition based on gait features has gained significant interest due to its wide range of applications in various fields. This paper proposes GenReGait, a robust method for gender recognition utilizing gait features.
Yue Fong Ti, Tee Connie, Michael Kah Ong Goh   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source