Results 41 to 50 of about 97,040 (311)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Specific features of competition functioning of martial arts elite sportsmen

Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2015
Purpose: to study competition functioning of martial arts elite sportsmen. Material: we analyzed 33 competition duels, studied specific features of application of 917 technical tactic actions by sportsmen. We used analysis of video-records of competition
Y. A. Radchenko
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Hunger strikes in prison: a legal perspective for psychiatrists [PDF]

, 2017
Hunger strikes in a custodial setting are complex to manage clinically, with associated legal and ethical complexities. Hunger strikes in Irish prisons have received, and are likely to continue to be the focus of, considerable media attention.
C. P. Dunne, E. Spain, Darius Whelan (12593644), Gautam Gulati (260985), Dunne, Colum P., G. Gulati, D. Whelan, Whelan, Darius, COLUM DUNNE (12349567), D. Meagher, DAVID MEAGHER (12346897), Gulati, Gautam, Meaghar, David, Spain, Eimear, EIMEAR SPAIN (12352291)   +14 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The Primacy of As-Built Drawings in the Management of Underground Utility Operations: A New Zealand Study

Buildings, 2021
There are increasing incidences of damages to underground utilities and services during maintenance and construction works. These have posed significant challenges to utility owners regarding the magnitude and costs associated with remediation works ...
Sami Maree, Funmilayo Ebun Rotimi, James Olabode Bamidele Rotimi   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The industrial unionism movement in Greece during the first years of the political change after the fall of the Junta (1974‑1981)

Cahiers Balkaniques, 2018
The announcement focuses on the industrial unionism movement in Greece, which was developed during the second half of the 70's. Firstly, the main political, economical and social transformations, following the collapse of the military dictatorship (1974),
Akis Palaiologos
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Toronto Civic Workers Bargaining Without a Base: The Significance of 2012

Studies in Social Justice, 2014
This article explores how the politics and economics of austerity has influenced collective bargaining between the CUPE Locals 79/416 and the city of Toronto.
Carlo Fanelli
doaj