Results 51 to 60 of about 97,040 (311)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A Democratic Right to Political Strikes
Political PhilosophyDemocratic politics in practice often lags far behind the democratic ideals that justify democracy in theory. Where democratic theory postulates the equality of citizens and the accountability of elected officials, democratic practice is often ...
Philipp Stehr
doaj +2 more sources
Moengo on strike: The Politics of Labour in Suriname’s Bauxite Industry
European Review of Latin American and Caribbean Studies, 2011 This article examines one crucial moment of contestation in colonial Suriname, the years 1941- 42, when sustained labour unrest in bauxite town Moengo led to the founding of the first mining unions.
Anouk de Koning
doaj +1 more source
Harbingers of crisis. Labour strikes in Yugoslavia (1958-1974) [PDF]
Istorija 20. Veka, 2019 The relative liberalization of the Yugoslav socialist economy and its limited transition to market economy have led to an increase in social differences.
Ivana Dobrivojević Tomić
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Revista Mundos do Trabalho, 2019 The main objective this article is to analyze the railroad workers strikes of the State of Bahia South-western Railway Co. Ltd.in 1927. The railroad workers strikes were one of the principal worker’s campaign in South Bahia during First Republic, with ...
Philipe Murillo Santana de Carvalho
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Three Strikes, then Two Strikes You're Out: Effects of Mandatory Sentencing Laws on Incarceration The Impact in Georgia [PDF]
The nexus of the “War on Drugs” and associated discriminatory sentencing policies like the “three strikes” rule and Georgia’s “Two Strikes” sentencing laws, have resulted in the disproportionate incarceration of marginalized populations in the United ...
Oruru, Mason
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
I'd Rather be Hanged for a Sheep than a Lamb The Unintended Consequences of 'Three-Strikes' Laws [PDF]
Strong sentences are common "tough on crime" tool used to reduce the incentives for individuals to participate in criminal activity. However, the design of such policies often ignores other margins along which individuals interested in participating in ...
Radha Iyengar
core +2 more sources