Results 71 to 80 of about 3,524 (216)

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Teachers campaign in Rio Grande do Sul: the long strike of 1985 and the bells in the public square

Revista Mundos do Trabalho, 2017
The aim of this text is to analyze the strike of teachers of the state system in 1985 in Rio Grande do Sul, from its preparation to its outcome. For it will be used primary sources of Zero Hora (ZH) newspaper, especially news, reports and chronicles of ...
Mauro Luiz Barbosa Marques
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

O sindicalismo deixou a crise para trás?: um novo ciclo de greves na década de 2000

Caderno CRH
O objetivo deste texto é retomar, de modo preliminar e indicativo, o debate sobre a crise ou o declínio histórico do movimento sindical. A questão que queremos levantar é a seguinte: a atividade sindical, na década de 2000, é um indicativo de que o ...
Armando Boito Jr., Paula Marcelino
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

“Things Fall Apart?” Prospects of Solidarity in a Precarious World

Social Inclusion
In this article, we examine the potential of solidarity to address global challenges in an increasingly precarious world. Solidarity involves individuals or groups supporting causes—whether ideas, people, or contexts—to combat marginalisation and ...
Matthew Mabefam, Kennedy Mbeva, Issah Wumbla   +2 more
doaj   +1 more source

FEATURES OF COLLECTIVE LABOR DISPUTE RESOLUTION IN THE STAVROPOL TERRITORY DURING THE SOVIET PERIOD

Гуманитарные и юридические исследования, 2021
The formation of the institution of collective labor disputes has passed a considerable historical period from the recognition of the right to labor conflicts to their complete denial and reception in labor relations.
T. Vysheslavova
doaj  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source