Results 71 to 80 of about 97,040 (311)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
University proceedings. Volga region. Humanities
Известия высших учебных заведений. Поволжский регион: Гуманитарные наукиBackground. This article examines the analysis of the activities of the local gen-darmerie to ensure state and public security in the North-Western Territory and the Polish provinces of the Russian Empire in the initial and climactic periods of the First
S.V. Ananyev
doaj +1 more source
Revue Française de Civilisation Britannique, 2017 The 1978-1979 « winter of Discontent » has now been thoroughly analysed as a political myth through which the industrial disputes of the winter 1978-1979 were defined as the sure sign of a larger crisis of state authority and of the social-democratic ...
Marc Lenormand
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The Effects of Labor Strikes on Consumer Demand: A Re-examination of Major League Baseball [PDF]
Previous research has concluded that the 1981 and 1994/95 Major League Baseball (MLB) strikes have caused short-term losses in attendance but have not resulted in any long-term effects on attendance. While total attendance at MLB games following the 1994/
Victor Matheson
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Do Strikes Kill? Evidence from New York State [PDF]
Concerns over the impacts of hospital strikes on patient welfare led to substantial delay in the ability of hospitals to unionize. Once allowed, hospitals unionized rapidly and now represent one of the largest union sectors of the U.S. economy.
Samuel A. Kleiner, Jonathan Gruber
core
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Strikes and Wages: A Test of a Signalling Model [PDF]
This paper describes a simple model of labor disputes based on the hypothesis that unions use strikes to infer the level of profitability of the firm. The implications of the model are then tested using data on wage outcomes, strike probabilities, and ...
David Card
core
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Mulheres, sindicato e organização política nas greves de 1917 em São Paulo
Revista Brasileira de HistóriaRESUMO Este artigo apresenta elementos da participação das mulheres nas Greves de 1917, em São Paulo. A mobilização que atingiu toda a cidade e transformou o movimento operário contou com grande número de trabalhadoras em suas fileiras.
Glaucia Cristina Candian Fraccaro
doaj +1 more source