Results 211 to 220 of about 1,577,348 (378)

Noncommutative open string, D-brane and duality [PDF]

open access: green, 2000
Jnanadeva Maharana, Shesansu Sekhar Pal
openalex   +1 more source

A Dynamic DNA Nano‐Antioxidant Targeting Galectin‐3 Attenuates Liver Fibrosis via Reducing Macrophage Oxidative Stress

open access: yesAdvanced Science, EarlyView.
This study developed a dynamic DNA nano‐antioxidant (DDN) for Galectin‐3 siRNA delivery, specifically targeting hepatic macrophages to suppress ROS‐driven fibrosis. DDN enhanced hepatic accumulation, restored NRF2 signaling, and attenuated oxidative stress, collagen deposition, and fibrotic progression in a CCl4‐induced cirrhosis model, demonstrating ...
Mengjia Peng   +6 more
wiley   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

open access: yesAdvanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha   +12 more
wiley   +1 more source

Reprogramming Tumor‐Associated Macrophages via Targeted NAT10 Inhibition to Enhance Colorectal Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
This study presents the sono‐sensitive nanorobot Sono@NAT10, which targets NAT10 condensates to reprogram tumor‐associated macrophages in colorectal cancer. By reducing the acetylation level of SRSF2 protein and activating HDAC10, Sono@NAT10 promotes M1 polarization, suppresses tumor progression, and strengthens immunotherapy. The approach demonstrates
Jiahao Zhu   +11 more
wiley   +1 more source

Timelike Hopf duality and type IIA * string solutions [PDF]

open access: green, 2000
C.N. Pope, A. Sadrzadeh, Sante R. Scuro
openalex   +1 more source

Multi‐Instably Mechanical Systems for Computing‐Storing Functions

open access: yesAdvanced Science, EarlyView.
Multi‐instably mechanical systems for the functions of scientific computing, logical operations, and data storage, i.e., solving fourth‐order ordinary differential equations (ODEs) by fourth‐order ODE solvers, realizing logical operations by digital logic gates, and stably storing data by mechanical memories.
Jiajun Wang   +3 more
wiley   +1 more source

Tensionless AdS3/CFT2 and single trace T T ¯ $$ T\overline{T} $$

open access: yesJournal of High Energy Physics
One of the few cases of AdS/CFT where both sides of the duality are under good control relates tensionless k = 1 strings on AdS3 to a two-dimensional symmetric product CFT. Building on prior observations, we propose an exact duality between string theory
Andrea Dei   +3 more
doaj   +1 more source

Rethinking the AI Paradigm for Solubility Prediction of Drug‑Like Compounds with Dual‐Perspective Modeling and Experimental Validation

open access: yesAdvanced Science, EarlyView.
Aqueous solubility governs drug delivery and bioavailability, yet its prediction remains challenging. Utilizing the largest curated dataset of drug‐like molecules, prediction models are constructed through dual‐perspective benchmarking. Stacking methods outperform advanced deep learning due to data constraints. These validated models enabled systematic
Qilin Zhu   +8 more
wiley   +1 more source

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