Results 121 to 130 of about 616,096 (295)

Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE–Tau Axis via Human Cerebral Organoids with Immuno‐SERS

open access: yesAdvanced Science, EarlyView.
Noninvasive and sensitive detection of tau protein dynamics across developmental stages and APOE genotypes remain a challenge in Alzheimer's disease (AD) research. This study reveals the dynamics of tau secretion in label‐free manner using surface‐enhanced Raman spectroscopy (SERS) and human cerebral organoids (hCOs). This study provides novel insights
Yongjae Jo   +11 more
wiley   +1 more source

Harnessing Machine Learning to Enhance Transition State Search with Interatomic Potentials and Generative Models

open access: yesAdvanced Science, EarlyView.
Comprehensive evaluation of MLIPs and generative models for TS search using an end‐to‐end benchmark platform. Success rates, TS quality, and barrier prediction errors are systematically compared across models. The results reveal key performance trade‐offs and provide actionable insights for improving ML‐based transition state search and reaction ...
Qiyuan Zhao   +9 more
wiley   +1 more source

Spatiotemporal Adaptations‐Driven Dynamic Thra Activation Simulates a Skin Wound Healing Response

open access: yesAdvanced Science, EarlyView.
This study uncovers the thyroid hormone receptor Thra as a pivotal regulator that spatiotemporally orchestrates dual‐phase skin repair. Epidermal Thra accelerates barrier restoration via glutathione‐driven keratin assembly, while dermal Thra establishes angiogenic niches through SAA3‐FN1‐mediated matrix remodeling.
Zeming Li   +15 more
wiley   +1 more source

Inhibition of Macrophage ARID3A Alleviates Myocardial Ischemia‐Reperfusion Injury After Heart Transplantation by Reducing THBS1/CD47 Signaling‐Mediated Neutrophil Extracellular Traps Formation

open access: yesAdvanced Science, EarlyView.
This study reveals that ARID3A in macrophages can transcriptionally regulate the THBS1‐CD47 axis after heart transplantation (HT), thereby inducing activated neutrophils to release NETs through the p38 MAPK signaling pathway. The itaconate derivative 4‐OI can inhibit ARID3A in macrophages and promote the accumulation of antioxidant factors, thereby ...
Hao Tian   +7 more
wiley   +1 more source

Unambiguous Quantum State Discrimination in a PT$\mathcal {PT}$‐Symmetric System of a Single Trapped Ion

open access: yesAdvanced Science, EarlyView.
An unambiguous quantum state discrimination for two nonorthogonal states is demonstrated using a single ion. By implementing a non‐Hermitian Hamiltonian with parity‐time‐reversal (PT) symmetry, two candidate states evolve with different speed and become orthogonal at specific time, hence can be discriminated unambiguously. Experiments are performed for
Chenhao Zhu   +5 more
wiley   +1 more source

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