Results 141 to 150 of about 44,120 (311)

Light and compressed gluinos at the LHC via string theory. [PDF]

open access: yesEur Phys J C Part Fields, 2017
AbdusSalam SS.
europepmc   +1 more source

Regge behavior saves String Theory from causality violations [PDF]

open access: green, 2015
G. D’Appollonio   +3 more
openalex   +1 more source

AI‐Driven Acceleration of Fluorescence Probe Discovery

open access: yesAdvanced Science, EarlyView.
We present PROBY, an AI model trained on large‐scale datasets to predict key photophysical properties and accelerate the discovery of target‐specific fluorescent probes. By screening a target‐annotated library, PROBY identifies candidate probes for diverse targets and could guide probe optimization, enabling a range of in vitro and in vivo imaging ...
Xuefeng Jiang   +18 more
wiley   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

open access: yesAdvanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying   +8 more
wiley   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu   +8 more
wiley   +1 more source

New Janus interfaces from four-dimensional $$N=3$$ N = 3 gauged supergravity

open access: yesEuropean Physical Journal C: Particles and Fields
We construct new supersymmetric Janus solutions from four-dimensional $$N=3$$ N = 3 gauged supergravity coupled to eight vector multiplets with $$SO(3)\times SU(3)$$ S O ( 3 ) × S U ( 3 ) gauge group.
Parinya Karndumri
doaj   +1 more source

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

open access: yesAdvanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu   +12 more
wiley   +1 more source

Twisted compactifications and conformal defects from ISO(3) $$\times $$ × U(1) F(4) gauged supergravity

open access: yesEuropean Physical Journal C: Particles and Fields
We study holographic solutions describing RG flows across dimensions from five-dimensional $$N=2$$ N = 2 SCFT to SCFTs in three and two dimensions using matter-coupled F(4) gauged supergravity with $$ISO(3)\times U(1)$$ I S O ( 3 ) × U ( 1 ) gauge group.
Parinya Karndumri
doaj   +1 more source

Home - About - Disclaimer - Privacy