Results 61 to 70 of about 307,464 (285)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Beyond Traditional Lateral Flow Assays: Enhancing Performance Through Multianalytical Strategies
BiosensorsMultiplex lateral flow assays are one of the greatest advancements in the world of rapid diagnostics, achieving the performance of several tests in one.
Eleni Lamprou +2 more
doaj +1 more source
Multi-mode control of strip-finishing-temperature in hot-strip mills
工程科学学报, 2019 At present, hot-rolled strip manufacturing has gradually exhibited more diversity and process complexity. Using the single control strategy, the traditional strip-finishing temperature-control mode shows some defects and deficiencies, for example, low ...
WANG Hai-yu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Rethinking Strip Searches by NSW Police [PDF]
, 2019 This report investigates the adequacy of the law regulating strip searches conducted by NSW Police. The report concludes that our laws are not strong enough to protect the public from unnecessary strip searches and do not provide clear guidance to police.
Grewcock, Michael ; https://orcid.org/ +1 more
core +2 more sources
Remarks on the Moser–Trudinger inequality
Advances in Nonlinear Analysis, 2013 We extend the Moser–Trudinger ...
Battaglia Luca, Mancini Gabriele
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Stripovska obravnava češkega narodnega preroda (problem Václava Hanke)
Slavistična Revija, 2014 Študija raziskuje stripovsko knjigo Šifra mistra Hanky ( Hankova šifra ) s poudarkom na deležu dokumentarnih sestavin in fikcije v zgodbi. Usmerjena je v vlogo Václava Hanke in Josefa Dobrovskega kot postav v tej zgodbi.
Eva Niklesová
doaj
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source