Results 31 to 40 of about 20,903 (219)

Load-bearing capacity of soil loaded with strip-shell foundations [PDF]

open access: yesИнженерно-строительный журнал, 2016
The paper describes the special features of the calculation based on the load-bearing capacity of soil loaded with strip-shell foundations which offer high efficiency in construction of medium and high-rise buildings on strongly compressible soils.
J.V. Naumkina   +2 more
doaj   +1 more source

Social Criticism about the 2019 Election Campaign in the Comic Strip Gump n Hell

open access: yesDewa Ruci: Jurnal Pengkajian dan Penciptaan Seni, 2021
Comic strips are a top-rated entertainment product. Supported by growing information technology, comic strips today are very accessible to almost all people.
Luqman Wahyudi, Sri Hesti Heriwati
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Flutter Control of a Quasi-three-dimensional Wing in Simplified Unsteady Flow using Forced Jet [PDF]

open access: yesمکانیک هوافضا
One of the special topics in the aeroelastic field is the flutter of the airplane wing at an index speed called the flutter speed, which, if this phenomenon is not controlled, there will be a possibility of destroying the structure (airplane wing ...
Alireza Ansari   +2 more
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Study on the Pressure-Bearing Law of Backfilling Material Based on Three-Stage Strip Backfilling Mining

open access: yesEnergies, 2020
During strip backfilling mining in coal mines, the backfilling material is the main support structure. Therefore, studying the pressure law of the backfilling material is essential for the safe and efficient mining of coal resources.
Xiaoping Shao   +7 more
doaj   +1 more source

Prediction Model of Strip Crown in Hot Rolling Process Based on Machine Learning and Industrial Data

open access: yesMetals, 2023
The strip crown in hot rolling has the characteristics of multivariablity, strong coupling and, nonlinearity. It is difficult to describe accurately using a traditional mechanism model.
Zhenhua Wang   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Vertical Vibration Model for Unsteady Lubrication in Rolls-Strip Interface of Cold Rolling Mills

open access: yesAdvances in Mechanical Engineering, 2012
According to the vertical vibration phenomena existing in cold rolling mills, the unsteady lubrication mechanism in roll gap and its influence to rolling stability was chosen as the case for analysis.
Xu Yang   +3 more
doaj   +1 more source

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