Results 271 to 280 of about 1,815,497 (360)

RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development

open access: yesAdvanced Science, EarlyView.
The study investigates the role of RACK7 in brain development using a conditional knockout mouse model. RACK7 deficiency results in developmental defects and abnormal astrocyte development by disrupting H3K27me3 chromatin binding. The underlying mechanism involves RACK7 interacting with the PRC2 complex to regulate the genomic localization of SUZ12 and
Fangfang Jiao   +9 more
wiley   +1 more source

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

open access: yesAdvanced Science, EarlyView.
Canopy FGF signaling regulator 2 (CNPY2) which is contributed to ERS is upregulated in the renal tubules of patients with diabetic nephropathy (DN). Mechanistically, CNPY2 may regulate ferroptosis and MAM integrity in renal tubular epithelial cells through PERK/ATF4/CHAC1 pathway, thereby promoting the progression of DN.
Jingfang Chen   +9 more
wiley   +1 more source

Impact of diabetes mellitus on 30-day mortality among acute stroke patients in northern Tanzania. [PDF]

open access: yesPLoS One
Kamabu EM   +15 more
europepmc   +1 more source

Resilient and Flexible Electrohydrodynamics Pumps for Human–Machine Interfaces

open access: yesAdvanced Science, EarlyView.
This study introduces resilient and flexible electrohydrodynamic (EHD) pumps designed to enhance human–machine interfaces. These pumps are both quiet and compact, featuring a unique electrode configuration that overcomes the typical limitations associated with dielectric breakdowns and subsequent permanent failures.
Yu Kuwajima   +13 more
wiley   +1 more source

Predictors of pre-hospital delay among stroke patients in Yekatit-12 hospital Addis Ababa, Ethiopia: unmatched case-control study. [PDF]

open access: yesInt J Emerg Med
Mamo BT   +7 more
europepmc   +1 more source

Micro‐Coil Neuromodulation at Single‐Cell and Circuit Levels for Inhibiting Natural Neuroactivity, Neutralizing Electric Neural Excitation, and Suppressing Seizures

open access: yesAdvanced Science, EarlyView.
Micromagnetic stimulation (µMS) offers a precise method for neural inhibition, complementing existing neuromodulation techniques. Using an implantable micro‐coil device, µMS selectively suppresses cortical activity with high spatial resolution. It effectively counteracts micro‐electrode stimulation and reduces seizure amplitude, highlighting its ...
Kayeon Kim   +11 more
wiley   +1 more source

Longitudinal, Multimodal Tracking Reveals Lasting Neurovascular Impact of Individual Microinfarcts

open access: yesAdvanced Science, EarlyView.
Jin et al. investigate the neurovascular impact of microinfarcts, revealing transient neural suppression with minimal cell death and recovery linked to vascular remodeling. Fast‐spiking interneurons exhibit reduced excitability, whereas regular‐spiking neurons showed increased bursting activity. Disruptions in low‐gamma phase locking suggest persistent
Yifu Jin   +9 more
wiley   +1 more source

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