Results 61 to 70 of about 6,731,060 (306)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

What can functional transcranial Doppler ultrasonography reveal about the cerebral lateralization of writing

FEBS Letters, EarlyView.
Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley   +1 more source

Stroke outcome in clinical trial patients deriving from different countries [PDF]

, 2008
<p><b>Background and Purpose:</b> Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across ...
Lyden, Patrick, Sacco, R.L., Atula, Sari, Lees, Kennedy R, Hacke, Werner, Marler, J.R., Marler, John R., Lees, K.R., Grotta, James, Sacco, Ralph L, Bath, Philip M W, Lyden, Patrick D., Sacco, Ralph, Grotta, J., Sacco, Ralph L., Lees, Kennedy R., Bath, Philip M.W., Bath, P.M.W., Ali, M., Ali, Myzoon, Lyden, P., Marler, John, Hacke, W., Grotta,, James, Marler, John R, Atula, S., Ali, Myzoon; id_orcid   +26 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Pengaruh Inovasi Jasa dan Harga terhadap Nilai yang Dirasakan Pasien di Stroke Center RS Al-Islam Bandung

Global Medical & Health Communication, 2015
Abstrak Rumah sakit sebagai salah satu industri jasa harus dapat menghasilkan produk barang maupun jasa dengan kualitas yang baik. Tujuan penelitian ini adalah ingin mengetahui pengaruh inovasi jasa dan harga pada nilai yang dirasakan pasien di Stroke ...
Siska Nia Irasanti, Yudi Azis, Wawang S. Sukarya   +2 more
doaj  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke

Frontiers in Cellular Neuroscience, 2020
Autophagy is a conserved process to maintains homeostasis via the degradation of toxic cell contents, which can either promote cell survival or accelerate cellular demise.
Jie Liu, Jie Liu, Jie Liu, Zhen-Ni Guo, Zhen-Ni Guo, Xiu-Li Yan, Shuo Huang, Shuo Huang, Shuo Huang, Jia-Xin Ren, Jia-Xin Ren, Yun Luo, Yun Luo, Yun Luo, Yi Yang, Yi Yang, Yi Yang   +16 more
doaj   +1 more source

Organization of stroke care in Turkey

, 2017
Stroke is one of the major health problems in Turkey. Since cerebrovascular disease is the second leading cause of death, institutional organizations are important to decrease the burden of stroke in our country.
Necioglu, Dilek, Ince, Birsen
core   +1 more source

Big Data Approaches to Phenotyping Acute Ischemic Stroke Using Automated Lesion Segmentation of Multi-Center Magnetic Resonance Imaging Data [PDF]

, 2019
Background and Purpose- We evaluated deep learning algorithms' segmentation of acute ischemic lesions on heterogeneous multi-center clinical diffusion-weighted magnetic resonance imaging (MRI) data sets and explored the potential role of this tool for ...
Lorentzen, Eric, Slowik, Agnieszka, Xu, Huichun,, Thijs, Vincent,, Kamnitsas, K, Mitchell, BD, Lorentzen, Eric,, Hancock, Brandon L., Rost, Natalia S., McArdle, Patrick F., MRI-Genetics Interface Exploration (MRI-GENIE), Hancock, Brandon L,, Rost, Natalia S,, Stanne, Tara M, Jern, Christina, Winzeck, S, Slowik, Agnieszka,, Mitchell, Braxton D., Schmidt, R, Mitchell, Braxton D,, Etherton, Mark R., Jiménez-Conde, Jordi,, McArdle, Patrick F,, Etherton, Mark R,, Xu, H, Winzeck, Stefan,, Vagal, Achala, Rost, NS, Sharma, Pankaj, Schirmer, Markus D., Sacco, Ralph L,, Rosand, Jonathan, Sacco, Ralph L., Schirmer, Markus D,, Worrall, Bradford B, Sacco, Ralph L, Sharma, P, Wasselius, Johan,, Bevan, Stephen,, Etherton, MR, Worrall, Bradford B,, Lemmens, R, Rosand, Jonathan,, Lund University., Donahue, K, Bouts, Mark J R J, Worrall, BB, Jern, C, Lindgren, Arne G,, McIntosh, Elissa C, Donahue, Kathleen, Lindgren, Arne G., Kittner, Steven J, Giese, Anne-Katrin,, Schirmer, MD, Mocking, Steven J T,, Bezerra, Raquel,, Hancock, BL, Xu, Huichun, Schmidt, Reinhold,, Giese, AK, Wu, O, Kittner, SJ, Rundek, T, Slowik, A, Kamnitsas, Konstantinos,, Kittner, Steven J,, Kittner, Steven J., Meschia, James F, Mocking, Steven J T, Irie, Robert E, Schmidt, Reinhold, Bouts, Mark J.RJ., Wu, Ona, Roquer, J, Roquer, Jaume,, Sharma, Pankaj,, Bouts, MJRJ, Jiménez-Conde, Jordi, Rost, Natalia S, Stanne, TM, Holmegaard, Lukas,, Schirmer, Markus D, Bouts, Mark J R J,, Roquer, Jaume, Donahue, Kathleen,, Frid, P, Lorentzen, E, McArdle, Patrick F, Holmegaard, L, Jern, Christina,, Rundek, Tatjana, Słowik, Agnieszka, Lindgren, Arne G, McIntosh, Elissa C., McIntosh, Elissa C,, Bouts, Mark J.R.J., Meschia, JF, Frid, Petrea, Wu, Ona,, Sacco, RL, Irie, Robert E., Bezerra, Raquel, Thijs, Vincent, Irie, Robert E,, Cole, John W, Jiménez-Conde, J, Genetics of Ischaemic Stroke Functional Outcome (GISCOME) Network, Bevan, S, Jane Maguire,, Jane Maguire, McIntosh, EC, Woo, D, Irie, RE, Hancock, Brandon L, Worrall, Bradford B., Mitchell, Braxton D, Mocking, Steven J.T., Maguire, Jane,, Maguire, Jane, Mocking, SJT, Kamnitsas, Konstantinos, McArdle, PF, Lemmens, Robin, Giese, Anne-Katrin, Wasselius, Johan, Cole, John W., Cole, John W,, Stanne, Tara M,, Bezerra, R, Rundek, Tatjana,, Stanne, Tara M., Maguire, J, Woo, Daniel, Thijs, V, Rosand, J, Holmegaard, Lukas, Bevan, Stephen, Vagal, A, Wasselius, J, Lemmens, Robin,, Meschia, James F., Lindgren, AG, Meschia, James F,, Etherton, Mark R, Woo, Daniel,, Cole, JW, Vagal, Achala,, Winzeck, Stefan, Frid, Petrea,, Frid, P., Woo, D., Lorentzen, Erik,, Giese, A. K., Jimenez-Conde, J., Etherton, M. R., Cole, J. W., Sharma, P., Vagal, A., Mocking, S. J. T., Lindgren, A. G., Donahue, K., Sacco, R. L., Schmidt, R., Bezerra, R., Slowik, A., Meschia, J. F., Rosand, J., Worrall, B. B., Mitchell, B. D., Lemmens, R., Kittner, S. J., Maguire, J., Xu, H. C., Wasselius, J., Roquer, J., Rundek, T., Wu, O., Kamnitsas, K., Bevan, S., Irie, R. E., Thijs, V., McIntosh, E. C., Schirmer, M. D., McArdle, P. F., Hancock, B. L., Rost, N. S., Winzeck, S.   +186 more
core   +1 more source

Early hospital readmission following stroke: the Florida Stroke Registry

, 2023
Background Hospital readmission is an important indicator of poor transition of care post-stroke. Data on characteristics of patients at highest risk for readmission is limited and necessary to inform effective interventions. The goal is to identify risk
Derias, Terry, Gutierrez, Carolina, Asdaghi, Negar, Gordon Perue, Gillian, Marulanda, Erika, Rundek, Tatjana, Brown, Scott C., Johnson, Karlon, Foster, Dianne, Romano, Jose G., Gardener, Hannah   +10 more
core   +1 more source