Results 31 to 40 of about 326,602 (266)

Allometric scaling of metabolic rate and cardiorespiratory variables in aquatic and terrestrial mammals

Physiological Reports, 2023
While basal metabolic rate (BMR) scales proportionally with body mass (Mb), it remains unclear whether the relationship differs between mammals from aquatic and terrestrial habitats. We hypothesized that differences in BMR allometry would be reflected in
Rebecca S. He, Stacy De Ruiter, Tristan Westover, Jason A. Somarelli, Ashley M. Blawas, Divya L. Dayanidhi, Ana Singh, Benjamin Steves, Samantha Driesinga, Lewis G. Halsey, Andreas Fahlman   +10 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Characteristics of High‐Performance Low‐Volume Hospitals in Acute Stroke Care

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background High patient volumes are associated with better stroke management and outcomes. However, in sparsely populated regions, patients with stroke frequently rely on low‐volume hospitals for acute care.
Han‐Yeong Jeong, Seong‐Eun Kim, Kyungbok Lee, Jong‐Moo Park, Hong‐Kyun Park, Yong‐Jin Cho, Jun Yup Kim, Beom Joon Kim, Tae Jung Kim, Soo Joo Lee, Jonguk Kim, Tai Hwan Park, Ji Sung Lee, Juneyoung Lee, Yong Uk Kwon, In Ok Bae, Gui Ok Kim, Philip B. Gorelick, Hee‐Joon Bae   +18 more
doaj   +1 more source

Effects of Mild Orthostatic Stimulation on Cerebral Pulsatile Hemodynamics

Frontiers in Physiology, 2019
The augmented cerebral hemodynamic pulsatility could lead to the elevated risk of cerebrovascular disease. To determine the impact of an acute orthostatic challenge on a pulsatile component of cerebral hemodynamics, mild lower body negative pressure ...
Yuka Ninomiya, Yuka Ninomiya, Tsubasa Tomoto, Tsubasa Tomoto, Tsubasa Tomoto, Shigehiko Ogoh, Tomoko Imai, Koki Takahashi, Jun Sugawara   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Stroke etiology and white matter burden in women with and without migraine

The Journal of Headache and Pain
Background Women with migraine, especially with aura (MA), have a higher risk of white matter hyperintensities (WMH) and ischemic stroke. We aimed to assess differences in stroke etiology between women with and without migraine and the impact of migraine
Anne E. Wilms, Nelleke van der Weerd, Thijs W. van Harten, Katie M. Linstra, Hendrikus J. A. van Os, Irene de Boer, Mark C. Kruit, Antoinette Maassen van den Brink, Marieke J. H. Wermer, Gisela M. Terwindt, On behalf of the CREW consortium   +10 more
doaj   +1 more source

The association of insular stroke with lesion volume

NeuroImage: Clinical, 2016
The insula has been implicated in many sequelae of stroke. It is the area most commonly infarcted in people with post-stroke arrhythmias, loss of thermal sensation, hospital acquired pneumonia, and apraxia of speech. We hypothesized that some of these results reflect the fact that: (1) ischemic strokes that involve the insula are larger than strokes ...
Nishanth Kodumuri, Rajani Sebastian, Cameron Davis, Joseph Posner, Eun Hye Kim, Donna C. Tippett, Amy Wright, Argye E. Hillis   +7 more
openaire   +3 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Lateral Ventricle Volume from Computed Tomography Scans Is Correlated with Pre-Stroke Impairment and Post-Stroke Cognitive Performance

Cerebral Circulation - Cognition and Behavior
Introduction: The link between neurodegenerative disease and stroke is well established and there is a need to understand pre-morbid brain anatomy to explain between-subject differences.
Till Schellhorn, Elakkyen Murugesu, Karoline Skogen, Eva Aamodt, Atle Bjørnerud, Mona Beyer, Ingvild Saltvedt, Bradley MacIntosh   +7 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source