Results 1 to 10 of about 10,735,506 (247)
Open Biology, 2023 Upon initial immune challenge, dendritic cells (DCs) migrate to lymph nodes and interact with fibroblastic reticular cells (FRCs) via C-type lectin-like receptor 2 (CLEC-2).
Shu En Lim +4 more
doaj +1 more source
Mesenchymal stromal cells for osteonecrosis [PDF]
Journal of Translational Medicine, 2020 AbstractOsteonecrosis (ON) is an acquired debilitating skeletal disorder, which is caused by a multitude of traumatic and non-traumatic etiological factors. Vascular damage, mechanical stress and increased intraosseous pressure have been discussed as contributors to ON.
S. Elgaz, H. Bonig, P. Bader
openaire +6 more sources
Endometrial stromal cell ferroptosis promotes angiogenesis in endometriosis
Cell Death Discovery, 2022 Endometriosis, a chronic disorder characterised by the presence of endometrial-like tissue outside the uterus, is associated with iron overload and oxidative stress in the lesion. Although it is well established that iron overload can trigger ferroptosis,
Guojing Li +10 more
semanticscholar +1 more source
Immune function and dysfunction are determined by lymphoid tissue efficacy
Disease Models & Mechanisms, 2022 Lymphoid tissue returns to a steady state once each immune response is resolved, and although this occurs multiple times throughout life, its structural integrity and functionality remain unaffected. Stromal cells orchestrate cellular interactions within
Spyridon Makris +5 more
doaj +1 more source
Macrophage – tumor cell interaction beyond cytokines
Frontiers in Oncology, 2023 Tumor cells communication with tumor associated macrophages is a highly important factor of tumor malignant potential development. For a long time, studies of this interaction were focused on a cytokine- and other soluble factors -mediated processes ...
Olga Kovaleva +6 more
doaj +1 more source
Mesenchymal stromal cell apoptosis is required for their therapeutic function
Nature Communications, 2021 Multipotent mesenchymal stromal cells (MSCs) ameliorate a wide range of diseases in preclinical models, but the lack of clarity around their mechanisms of action has impeded their clinical utility.
S. H. Pang +15 more
semanticscholar +1 more source
Frontiers in Oncology, 2021 BackgroundTumor microenvironment (TME) provides the essential prerequisite niche for promoting cancer progression and metastasis. Calebin A, a component of Curcuma longa, has long been investigated as a safe multitargeted agent with antitumor and anti ...
Constanze Buhrmann +7 more
doaj +1 more source
Characterization of Leptin Receptor+ Stromal Cells in Lymph Node
Frontiers in Immunology, 2022 Lymph node (LN)-resident stromal cells play an essential role in the proper functioning of LNs. The stromal compartment of the LN undergoes significant compensatory changes to produce a milieu amenable for regulation of the immune response.
Liwei Jiang +15 more
doaj +1 more source
The Stromal Activity of Mesenchymal Stromal Cells [PDF]
Transfusion Medicine and Hemotherapy, 2008 SUMMARY: The mechanism that regulates self-renewal and differentiation of hematopoietic stem cells (HSC) is a central question in stem cell biology that might ultimately lead to reliable protocols for in vitro expansion of HSC. Cellular fate is governed by cell-cell interaction with the microenvironment in the bone marrow, the stem cell niche ...
Anthony D. Ho +2 more
openaire +3 more sources
Frontiers in Pharmacology, 2022 Endometriosis (EMs) is defined as the presence of tissue somewhat resembling endometrial glands and stroma outside the uterus; the retrograded endometrium grows in the peritoneal cavity and elicits fibrosis.
Yanqin Zhang +8 more
doaj +1 more source