Results 91 to 100 of about 548,364 (335)

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

A novel and alternative in vitro method using microwave to study the epithelial-stromal interactions [PDF]

, 2009
The goal of the present work was to obtain a simple and reproducible experimental model that would maintain the characteristics of the extracellular physiological environment of breast epithelial cells, both in factors as well as stromal structure, on ...
Calvo, Juan Carlos, Pistone Creydt, Virginia, Sacca, Paula Alejandra, Tesone, Amelia Julieta   +3 more
core  

Marrow-derived stromal cell delivery on fibrin microbeads can correct radiation-induced wound-healing deficits. [PDF]

, 2013
Skin that is exposed to radiation has an impaired ability to heal wounds. This is especially true for whole-body irradiation, where even moderate nonlethal doses can result in wound-healing deficits.
Gaberman, Elena, Gorodetsky, Raphael, Levdansky, Lilia, Mackenzie, Natalia C, McBride, William H, Micewicz, Ewa D, Xie, Michael W   +6 more
core   +1 more source

Adipose-Derived Stromal/Stem Cells [PDF]

Cells, 2020
Adipose tissue is a rich, ubiquitous, and easily accessible source for multipotent mesenchymal stromal/stem cells (MSCs), so-called adipose-derived stromal/stem cells (ASCs) [...]
openaire   +6 more sources

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection. [PDF]

, 2020
Single-cell transcriptomics was used to profile cells of the normal murine middle ear. Clustering analysis of 6770 transcriptomes identified 17 cell clusters corresponding to distinct cell types: five epithelial, three stromal, three lymphocyte, two ...
Draf, Clara, Fisch, Kathleen M, Kurabi, Arwa, Nasamran, Chanond A, Pak, Kwang, Ryan, Allen F, Webster, Nicholas   +6 more
core  

Microenvironment in neuroblastoma: Isolation and characterization of tumor-derived mesenchymal stromal cells [PDF]

, 2018
Background: It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterized MSCs isolated and expanded from
Apuzzo T., Avanzini M. A., Calcaterra V., Catenacci L., Croce S., D'Angelo P., Di Benedetto V., Maltese A., Mantelli M., Moretta A., Pelizzo G., Scavo E., Stassi G., Todaro M., Veschi V.   +14 more
core   +1 more source

CD10 expression in gastric carcinoma is correlated with tumor grade and survival

Universa Medicina, 2019
Background Gastric carcinoma (GC) is the most common non-skin malignancy in Iranian men and the second leading cause of cancer-related mortality. Invasion and metastasis are considered as the major causes of cancer-related morbidity and mortality ...
Amir Hosein Jafarian, Melika Kooshki Forooshani, Leila Takallou, Nema Mohamadian Roshan   +3 more
doaj   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Stromal cell-expressed malignant gene patterns contribute to the progression of squamous cell carcinomas across different sites

Frontiers in Genetics
BackgroundSquamous cell carcinomas (SCCs) across different anatomical locations possess common molecular features. Recent studies showed that stromal cells may contribute to tumor progression and metastasis of SCCs.
Kaiyan Qi, Guangqi Li, Yuanjun Jiang, Xuexin Tan, Qiao Qiao   +4 more
doaj   +1 more source