Results 101 to 110 of about 10,735,605 (346)

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Identification of Stromal Cells in Spleen Which Support Myelopoiesis

Frontiers in Cell and Developmental Biology, 2019
Stromal cells in spleen organize tissue into red pulp, white pulp and marginal zone, and also interact with hematopoietic cells to regulate immune responses.
Hong Kiat Lim, Hong Kiat Lim, Helen C. O’Neill   +2 more
doaj   +1 more source

BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression.

Journal of Clinical Investigation, 2013
BM mesenchymal stromal cells (BM-MSCs) support multiple myeloma (MM) cell growth, but little is known about the putative mechanisms by which the BM microenvironment plays an oncogenic role in this disease. Cell-cell communication is mediated by exosomes.
A. Roccaro, A. Sacco, P. Maiso, A. Azab, Y. Tai, M. Reagan, F. Azab, L. Flores, F. Campigotto, E. Weller, K. Anderson, D. Scadden, I. Ghobrial   +12 more
semanticscholar   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Stromal cell-expressed malignant gene patterns contribute to the progression of squamous cell carcinomas across different sites

Frontiers in Genetics
BackgroundSquamous cell carcinomas (SCCs) across different anatomical locations possess common molecular features. Recent studies showed that stromal cells may contribute to tumor progression and metastasis of SCCs.
Kaiyan Qi, Guangqi Li, Yuanjun Jiang, Xuexin Tan, Qiao Qiao   +4 more
doaj   +1 more source

Mesenchymal Stromal Cells: New Directions [PDF]

Cell Stem Cell, 2012
Research into mesenchymal stromal/stem cells (MSCs) has been particularly exciting in the past five years. Our understanding of mechanisms of MSC-mediated tissue regeneration has undergone considerable evolution. Recent investigation of the primary in situ counterpart of cultured MSCs has led to fresh insights into MSC physiology and its role in the ...
openaire   +5 more sources

Stromal gene signatures in large-B-cell lymphomas.

New England Journal of Medicine, 2008
BACKGROUND The addition of rituximab to combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), or R-CHOP, has significantly improved the survival of patients with diffuse large-B-cell lymphoma.
G. Lenz, George W. Wright, S. Dave, Wenming Xiao, J. Powell, Huaqing Zhao, Wei Xu, Bruce K. Tan, N. Goldschmidt, J. Iqbal, J. Vose, M. Bast, K. Fu, D. Weisenburger, T. Greiner, J. Armitage, A. Kyle, L. May, R. Gascoyne, J. Connors, G. Trøen, H. Holte, S. Kvaløy, D. Dierickx, G. Verhoef, J. Delabie, E. Smeland, P. Jares, A. Martínez, A. López-Guillermo, E. Montserrat, E. Campo, R. Braziel, T. Miller, L. Rimsza, J. Cook, B. Pohlman, J. Sweetenham, R. Tubbs, R. Fisher, E. Hartmann, A. Rosenwald, G. Ott, G. Ott, H. Müller-Hermelink, D. Wrench, T. Lister, E. Jaffe, W. Wilson, W. C. Chan, L. Staudt   +50 more
semanticscholar   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Recognizing Epithelial Cells in Prostatic Glands Using Deep Learning

Cells
Artificial intelligence (AI) is becoming an integral part of pathological assessment and diagnostic procedures in modern pathology. As most prostate cancers (PCa) arise from glandular epithelial tissue, an AI-based methodology has been developed to ...
Liton Devnath, Puneet Arora, Anita Carraro, Jagoda Korbelik, Mira Keyes, Gang Wang, Martial Guillaud, Calum MacAulay   +7 more
doaj   +1 more source