Results 141 to 150 of about 11,256,402 (404)

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Lymphotoxin-sensitive microenvironments in homeostasis and inflammation

Frontiers in Immunology, 2012
Stromal cell micro-microenvironments within lymphoid tissues are designed to support immune cell homeostasis and to regulate ongoing immune responses to pathogens.
Bryant eBoulianne, Elisa Almeida Porfilio, Natalia ePikor, Jennifer eGommerman   +3 more
doaj   +1 more source

Organotypic stromal cells impact endothelial cell transcriptome in 3D microvessel networks [PDF]

, 2022
Matthew B. Curtis, Natalie H. Kelly, Christopher C.W. Hughes, Steven C. George   +3 more
openalex   +1 more source

Megakaryocytes Enhance Mesenchymal Stromal Cells Proliferation and Inhibit Differentiation [PDF]

, 2017
Megakaryocytes (MKs) can induce proliferation of calvarial osteoblasts [Ciovacco et al., 2009], but this same phenomenon has not been reported for bone marrow stromal populations from long bones.
Alvarez, Marta B., Arman, Hussain E., Bidwell, Joseph P., Childress, Paul J., Chu, Tien-Min Gabriel, Emmakah, Arbi M., Goebel, William S., Kacena, Melissa A.   +7 more
core   +2 more sources

Bone marrow stromal/stem cell-derived extracellular vesicles regulate osteoblast activity and differentiation in vitro and promote bone regeneration in vivo

Scientific Reports, 2016
Emerging evidence suggests that extracellular vesicles (EVs) are secreted by diverse tissues and play important roles in cell-cell communication, organ interactions and tissue homeostasis.
Yunhao Qin, Lian Wang, Zhengliang Gao, Genyin Chen, Changqing Zhang   +4 more
semanticscholar   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

In Vitro Effect of Neopterin on Splenic Mast Cell Development in Senescence Accelerated Mice (SAM)

Pteridines, 2007
Neopterin is produced by monocytes and is a useful biomarker of inflammatory responses. We found that neopterin enhances granulopoiesis, but suppresses B-lymphopoiesis triggered by the positive- and negative regulations of cytokines produced by stromal ...
Harada Tomonori, Tsuboi Isao, Yuda Miyuki, Wakasugi Kazunori, Aizawa Shin   +4 more
doaj   +1 more source

Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells

Haematologica, 2013
The melanoma cell adhesion molecule defines mesenchymal stromal cells in the human bone marrow that regenerate bone and establish a hematopoietic microenvironment in vivo.
Sabine Stopp, Martin Bornhäuser, Fernando Ugarte, Manja Wobus, Matthias Kuhn, Sebastian Brenner, Sebastian Thieme   +6 more
doaj   +1 more source

Extracellular Vesicles from Different Sources of Mesenchymal Stromal Cells Have Distinct Effects on Lung and Distal Organs in Experimental Sepsis [PDF]

, 2023
Natália Blanco, NAOMY SOL FERNANDES MACHADO, Lígia Lins de Castro, Mariana A. Antunes, Christina Maeda Takiya, Monique R. O. Trugilho, Luana R. Silva, Adriana Franco Paes Leme, Romênia R. Domingues, Bianca Alves Pauletti, Beatriz Toja de Miranda, Johnatas D. Silva, Claúdia C. dos Santos, Pedro Leme Silva, Patrícia R. M. Rocco, Fernanda Ferreira Cruz   +15 more
openalex   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source