Results 11 to 20 of about 11,256,402 (404)

Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis

Stem cell research & therapeutics, 2022
Osteoarthritis, as a degenerative disease, is a common problem and results in high socioeconomic costs and rates of disability. The most commonly affected joint is the knee and characterized by progressive destruction of articular cartilage, loss of ...
Xiao-Na Xiang, Siyi Zhu, Hong-Chen He, Xi Yu, Yang Xu, Cheng-qi He   +5 more
semanticscholar   +1 more source

Endometrial stromal cell ferroptosis promotes angiogenesis in endometriosis

Cell Death Discovery, 2022
Endometriosis, a chronic disorder characterised by the presence of endometrial-like tissue outside the uterus, is associated with iron overload and oxidative stress in the lesion. Although it is well established that iron overload can trigger ferroptosis,
Guojing Li, Yu Lin, Yili Zhang, Nihao Gu, Bingxin Yang, Shan Shan, Na Liu, Ouyang Jing, Yisai Yang, Feng Sun, Hong Xu   +10 more
semanticscholar   +1 more source

Mesenchymal stromal cell apoptosis is required for their therapeutic function

Nature Communications, 2021
Multipotent mesenchymal stromal cells (MSCs) ameliorate a wide range of diseases in preclinical models, but the lack of clarity around their mechanisms of action has impeded their clinical utility.
S. H. Pang, J. D’Rozario, Senora Mendonca, T. Bhuvan, N. Payne, D. Zheng, A. Hisana, Georgia Wallis, A. Barugahare, D. Powell, J. Rautela, N. Huntington, G. Dewson, D. Huang, D. Gray, T. Heng   +15 more
semanticscholar   +1 more source

Ferroptosis induced by iron overload promotes fibrosis in ovarian endometriosis and is related to subpopulations of endometrial stromal cells

Frontiers in Pharmacology, 2022
Endometriosis (EMs) is defined as the presence of tissue somewhat resembling endometrial glands and stroma outside the uterus; the retrograded endometrium grows in the peritoneal cavity and elicits fibrosis.
Yanqin Zhang, Xinyu Liu, Mengqi Deng, Chunyu Xu, Yubo Zhang, Di Wu, Fan Tang, Ruiye Yang, Jinwei Miao   +8 more
doaj   +1 more source

Single cell RNA-sequencing profiling to improve the translation between human IBD and in vivo models

Frontiers in Immunology, 2023
Inflammatory bowel disease (IBD) is an umbrella term for two conditions (Crohn’s Disease and Ulcerative Colitis) that is characterized by chronic inflammation of the gastrointestinal tract.
Erik P. Karmele, Ana Laura Moldoveanu, Irem Kaymak, Bat-Erdene Jugder, Rebecca L. Ursin, Kyle J. Bednar, Daniele Corridoni, Tatiana Ort   +7 more
doaj   +1 more source

Utilizing osteocyte derived factors to enhance cell viability and osteogenic matrix deposition within IPN hydrogels [PDF]

, 2020
Many bone defects arising due to traumatic injury, disease, or surgery are unable to regenerate, requiring intervention. More than four million graft procedures are performed each year to treat these defects making bone the second most commonly ...
Hoey, David A., Parmentier, Laurens, Riffault, Mathieu   +2 more
core   +1 more source

Characterization of Leptin Receptor+ Stromal Cells in Lymph Node

Frontiers in Immunology, 2022
Lymph node (LN)-resident stromal cells play an essential role in the proper functioning of LNs. The stromal compartment of the LN undergoes significant compensatory changes to produce a milieu amenable for regulation of the immune response.
Liwei Jiang, Liwei Jiang, Mine Yilmaz, Mayuko Uehara, Cecilia B. Cavazzoni, Vivek Kasinath, Jing Zhao, Said Movahedi Naini, Xiaofei Li, Naima Banouni, Paolo Fiorina, Su Ryon Shin, Stefan G. Tullius, Jonathan S. Bromberg, Peter T. Sage, Reza Abdi   +15 more
doaj   +1 more source

Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells

Reproduction and Fertility, 2021
Chlamydia trachomatis is the most commonly diagnosed sexually transmitted infection in the UK, with over 200,000 positive diagnoses annually. The infection is thought to cause reproductive complications including problems in conceiving a pregnancy ...
Megan Brown, Mick Rae, Nick Wheelhouse
doaj   +1 more source

Tumor-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression

Nature Materials, 2020
Stromal stiffening accompanies malignancy, compromises treatment and promotes tumour aggression. Clarifying the molecular nature and the factors that regulate stromal stiffening in tumours should identify biomarkers to stratify patients for therapy and ...
O. Maller, A. Drain, Alexander S Barrett, S. Borgquist, S. Borgquist, B. Ruffell, Igor Zakharevich, Thanh T. Pham, T. Gruosso, H. Kuasne, J. Lakins, I. Acerbi, J. M. Barnes, T. Nemkov, Aastha Chauhan, J. Gruenberg, A. Nasir, Ó. Bjarnadóttir, Z. Werb, P. Kabos, Yunni-Yi Chen, E. Hwang, Morag Park, L. Coussens, A. Nelson, K. Hansen, K. Hansen, V. Weaver   +27 more
semanticscholar   +1 more source

Stromal cells

Frontiers in Bioscience, 2009
Stromal cells, or mesenchymal stem cells, are adherent clonogenic cells that can form colonies. They are mainly isolated from bone marrow but can also be found in umbilical cord blood, adipose tissues and amniotic fluids. These stem cells are easy to culture in vitro, and can differentiate into osteoblasts, chondrocytes, or adipocytes when stimulated ...
Vayssade, M., Nagel, M.D.
openaire   +3 more sources