Results 11 to 20 of about 10,735,605 (346)

Single cell RNA-sequencing profiling to improve the translation between human IBD and in vivo models

Frontiers in Immunology, 2023
Inflammatory bowel disease (IBD) is an umbrella term for two conditions (Crohn’s Disease and Ulcerative Colitis) that is characterized by chronic inflammation of the gastrointestinal tract.
Erik P. Karmele, Ana Laura Moldoveanu, Irem Kaymak, Bat-Erdene Jugder, Rebecca L. Ursin, Kyle J. Bednar, Daniele Corridoni, Tatiana Ort   +7 more
doaj   +1 more source

Mesenchymal Stromal Cells Support Endometriotic Stromal CellsIn Vitro [PDF]

Stem Cells International, 2018
Endometriosis is an inflammatory disease marked by ectopic growth of endometrial cells. Mesenchymal stromal cells (MSC) have immunosuppressive properties that have been suggested as a treatment for inflammatory diseases. Therefore, the aim herein was to examine effects of allogeneic MSC on endometriosis-derived cellsin vitroas a potential therapy for ...
Mikael Engman, Sebastian Gidlöf, Sebastian Gidlöf, Bartosz Bezubik, Cecilia Götherström, Fawaz Abomaray   +5 more
openaire   +3 more sources

Interplay between Solid Tumors and Tumor Microenvironment

Frontiers in Immunology, 2022
Over the past few decades, basic studies aimed at curing patients with cancer have been constantly evolving. A myriad of mechanistic studies on physiological changes and related factors in tumor growth and metastasis have been reported. Recently, several
Seung-Jin Kim, Seung-Jin Kim, Dipendra Khadka, Jae Ho Seo, Jae Ho Seo   +4 more
doaj   +1 more source

Stromal cells of the mouse spleen [PDF]

Frontiers in Immunology, 2012
The composition and function of stromal cells in the white pulp of the spleen resemble to a large extent the situation in other secondary lymphoid organs such as lymph nodes. The stromal cells play an important role in the support and guidance of lymphocytes and myeloid cells in the T and B cell zones of the spleen.
den Haan, J.M.M., Mebius, R.E., Kraal, G.   +2 more
openaire   +5 more sources

B Cell–Activating Factor Promotes B Cell Survival in Ectopic Lymphoid Tissues in Nasal Polyps

Frontiers in Immunology, 2021
Ectopic lymphoid tissues (eLTs) characterized by B cell aggregation contribute to the local immunoglobulin production in nasal polyps (NPs). B cell-activating factor (BAFF) is vital for B cell survival, proliferation, and maturation.
Zhe-Zheng Wang, Jia Song, Hai Wang, Jing-Xian Li, Qiao Xiao, Ze Yu, Jin-Xin Liu, Zheng Liu   +7 more
doaj   +1 more source

Comprehensive Comparison of Amnion Stromal Cells and Chorion Stromal Cells by RNA-Seq [PDF]

International Journal of Molecular Sciences, 2021
Mesenchymal stromal cells derived from the fetal placenta, composed of an amnion membrane, chorion membrane, and umbilical cord, have emerged as promising sources for regenerative medicine. Here, we used next-generation sequencing technology to comprehensively compare amniotic stromal cells (ASCs) with chorionic stromal cells (CSCs) at the molecular ...
Jones, Brielle, Li, Chaoyang, Park, Min Sung, Lerch, Anne, Jacob, Vimal, Johnson, Nicholas, Kuang, Jin-Qiang, Dhall, Sandeep, Sathyamoorthy, Malathi   +8 more
openaire   +3 more sources

Tumor-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression

Nature Materials, 2020
Stromal stiffening accompanies malignancy, compromises treatment and promotes tumour aggression. Clarifying the molecular nature and the factors that regulate stromal stiffening in tumours should identify biomarkers to stratify patients for therapy and ...
O. Maller, A. Drain, Alexander S Barrett, S. Borgquist, S. Borgquist, B. Ruffell, Igor Zakharevich, Thanh T. Pham, T. Gruosso, H. Kuasne, J. Lakins, I. Acerbi, J. M. Barnes, T. Nemkov, Aastha Chauhan, J. Gruenberg, A. Nasir, Ó. Bjarnadóttir, Z. Werb, P. Kabos, Yunni-Yi Chen, E. Hwang, Morag Park, L. Coussens, A. Nelson, K. Hansen, K. Hansen, V. Weaver   +27 more
semanticscholar   +1 more source

Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer

EMBO Journal, 2020
The tumour stroma regulates nearly all stages of carcinogenesis. Stromal heterogeneity in human triple‐negative breast cancers (TNBCs) remains poorly understood, limiting the development of stromal‐targeted therapies.
Sunny Z. Wu, D. Roden, Chenfei Wang, Holly Holliday, K. Harvey, Aurélie S. Cazet, K. Murphy, Brooke A. Pereira, G. Al-Eryani, N. Bartonicek, Rui Hou, J. Torpy, S. Junankar, Chia-Ling Chan, Chuan En Lam, M. Hui, L. Gluch, J. Beith, A. Parker, E. Robbins, D. Segara, C. Mak, C. Cooper, S. Warrier, A. Forrest, J. Powell, S. O'toole, Thomas R. Cox, P. Timpson, E. Lim, X. Liu, A. Swarbrick   +31 more
semanticscholar   +1 more source

A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration

Nature Communications, 2020
Bone marrow stromal cells (BMSCs) are versatile mesenchymal cell populations underpinning the major functions of the skeleton, a majority of which adjoin sinusoidal blood vessels and express C-X-C motif chemokine ligand 12 (CXCL12).
Yuki Matsushita, M. Nagata, K. Kozloff, Joshua D. Welch, Koji Mizuhashi, Nicha Tokavanich, Shawn A. Hallett, D. Link, T. Nagasawa, W. Ono, N. Ono   +10 more
semanticscholar   +1 more source

Mesenchymal stromal cells and autoimmunity [PDF]

International Immunology, 2017
Abstract Mesenchymal stromal cells (MSCs) are committed progenitors of mesodermal origin that are found virtually in every organ and exhibit multilineage differentiation into osteocytes, adipocytes and chondrocytes. MSCs also mediate a wide spectrum of immunoregulatory activities that usually dampen innate and adaptive immune responses ...
Lizzia Raffaghello, Vito Pistoia
openaire   +4 more sources