Results 311 to 320 of about 11,256,402 (404)

PKN2 signalling induces stromal cell protrusions to preserve lymph node structural integrity

Acton S, Millward L, Benjamin A, Makris S, Horsnell H, Menezes S, Shewring D, Tape C, Saez P, Cameron A, de Winde C.   +10 more
europepmc   +1 more source

Targeting bone marrow mesenchymal stromal cell-derived IL-6 to overcome acute myeloid leukemia chemoresistance. [PDF]

Blood Adv
Hou D, Cai D, Dai W, Liao X, Tan M, Zheng X, Wang L, Liu J, Wang J, Wang X, Fu Q, Huang H.   +11 more
europepmc   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Mesenchymal stromal cell-laden hydrogels in tissue regeneration: insights from preclinical and clinical research. [PDF]

Front Pharmacol
Barbon S, Rajendran S, Banerjee A, Parnigotto PP, De Caro R, Macchi V, Porzionato A.   +6 more
europepmc   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Extracellular vesicle bioactivity and potential for clinical development are determined by mesenchymal stromal cell clonal subtype. [PDF]

Stem Cell Res Ther
Ioannou S, Kay AG, Stone AP, Rand E, Elberfeld S, Bolton W, Larson T, Crossland RE, Kehoe O, Mentlak DA, Wang XN, MacDonald C, Genever PG.   +12 more
europepmc   +1 more source

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

Functional improvements correlate with enhanced quality of life following mesenchymal stromal cell therapy in chronic spinal cord injury. [PDF]

Sci Rep
Jafar H, Jamali F, Al-Hattab D, Ammar A, Al-Hayali A, Sroji H, Al Shudifat A, El Adwan N, Awidi A.   +8 more
europepmc   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Hacking Extracellular Vesicles: Using Vesicle-Related Tags to Engineer Mesenchymal Stromal Cell-Derived Extracellular Vesicles. [PDF]

Pharmaceutics
Scattini G, Pianigiani G, Capomaccio S, Ceccarini MR, Mecocci S, Musa L, Avellini L, Barbato O, Bufalari A, Casagrande Proietti P, Gialletti R, Sulla A, Beccari T, Pascucci L.   +13 more
europepmc   +1 more source