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Stromal Cells in the Tumor Microenvironment
2018The tumor microenvironment comprises a mass of heterogeneous cell types, including immune cells, endothelial cells, and fibroblasts, alongside cancer cells. It is increasingly becoming clear that the development of this support niche is critical to the continued uncontrolled growth of the cancer.
Denton, A. E. +2 more
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Reinventing mesenchymal stromal cells
Cytotherapy, 2012The life-saving impact of chemotherapy and radiation has been as remarkable and momentous as any advance in the history of medicine. This becomes even more signifi cant when we remind ourselves that 50 years ago nearly all leukemias, lymphomas and aggressive solid tumors were fatal, and that nearly everything in oncology before the 20th century was a ...
Jakub Tolar, Miroslav Tolar
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The CD9 Molecule on Stromal Cells
Leukemia & Lymphoma, 2000Numerous functions have been attributed to CD9 and other members of the transmembrane 4 (TM4) superfamily. CD9 is thought to be involved in cell proliferation, differentiation, motility and survival. It may also function as part of toxin and virus receptor complexes.
Paul W. Kincade +2 more
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Decidualisation of cervical stromal cells
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2004Control of cervical function is poorly understood. The major structural component of the cervix is collagen and peri-partum cervical changes are largely due to the action of collagenase, either released by resident cells or derived from an influx of neutrophils.
Rodney W. Kelly +2 more
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The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape
Nature Immunology, 2021M. D. de Jong +15 more
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Transplantation, 2009
Discovered more than 40 years ago, the biological features of multipotent mesenchymal stromal cells (MSC) were progressively compared first with hematopoietic stem cells (HSC) and, more recently, with embryonic stem cells (ESC). Although these comparisons have been crucial in helping to clarify their nature, there is now a robust amount of data ...
DOMINICI, Massimo +3 more
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Discovered more than 40 years ago, the biological features of multipotent mesenchymal stromal cells (MSC) were progressively compared first with hematopoietic stem cells (HSC) and, more recently, with embryonic stem cells (ESC). Although these comparisons have been crucial in helping to clarify their nature, there is now a robust amount of data ...
DOMINICI, Massimo +3 more
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Immunosuppression by Intestinal Stromal Cells
2018This chapter summarizes evidence that intestinal myofibroblasts, also called intestinal stromal cells, are derived in the adult from tissue mesenchymal stem cells under homeostasis and may be replenished by bone marrow mesenchymal stromal (stem) cells that are recruited after severe intestinal injury.
Don W. Powell, Iryna V. Pinchuk
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2013
In addition to being an energy reservoir, adipose tissue is now regarded as an active endocrine organ that is crucial to the maintenance of systemic energy homeostasis. However, obese adipose tissue, particularly visceral adipose tissue, is thought to be a key contributor to the development of insulin resistance and the clinical consequences of ...
Sahohime Matsumoto, Ichiro Manabe
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In addition to being an energy reservoir, adipose tissue is now regarded as an active endocrine organ that is crucial to the maintenance of systemic energy homeostasis. However, obese adipose tissue, particularly visceral adipose tissue, is thought to be a key contributor to the development of insulin resistance and the clinical consequences of ...
Sahohime Matsumoto, Ichiro Manabe
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Stromal Cell Responses in Infection
2018Stromal cells and the immune functions that they regulate underpin multiple aspects of host defence, but the study of stromal cells as targets of infection and as regulators of anti-infective immunity is in its infancy and still limited to a few well-worked examples.
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Journal of Cell Science, 1988
ABSTRACT Evidence for the hypothesis that there are stromal stem cells present in the soft connective tissues associated with marrow and bone surfaces that are able to give rise to a number of different cell lines is reviewed. The lines are currently designated fibroblastic, reticular, adipocytic and osteogenic.
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ABSTRACT Evidence for the hypothesis that there are stromal stem cells present in the soft connective tissues associated with marrow and bone surfaces that are able to give rise to a number of different cell lines is reviewed. The lines are currently designated fibroblastic, reticular, adipocytic and osteogenic.
openaire +3 more sources