Results 41 to 50 of about 10,735,605 (346)
Mesenchymal stromal cells in the thymus
Inflammation and Regeneration, 2022 AbstractThe microenvironment of the thymus is composed of a group of stromal cells that include endoderm-derived thymic epithelial cells (TECs) and mesenchymal stromal cells such as fibroblasts and serves as a site for the development of T cells. TECs are known to play an essential role in T cell differentiation and selection. Mesenchymal stromal cells
openaire +3 more sources
Nature Materials, 2019 Hydrogels serve as valuable tools for studying cell–extracellular matrix interactions in three-dimensional environments that recapitulate aspects of native extracellular matrix.
Claudia Loebel, R. Mauck, J. Burdick
semanticscholar +1 more source
Remodeling of Stromal Cells and Immune Landscape in Microenvironment During Tumor Progression
Frontiers in Oncology, 2021 The molecular understanding of carcinogenesis and tumor progression rests in intra and inter-tumoral heterogeneity. Solid tumors confined with vast diversity of genetic abnormalities, epigenetic modifications, and environmental cues that differ at each ...
Leena Arora, Durba Pal
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Cells, 2023 Corneal opacification or scarring is one of the leading causes of blindness worldwide. Human limbus-derived stromal/mesenchymal stem cells (hLMSCs) have the potential of clearing corneal scarring. In the current preclinical studies, we aimed to determine
Mukesh Damala +4 more
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Mechanisms of mesenchymal stem/stromal cell function
Stem cell research & therapeutics, 2016 The past decade has seen an explosion of research directed toward better understanding of the mechanisms of mesenchymal stem/stromal cell (MSC) function during rescue and repair of injured organs and tissues.
Jeffrey L Spees, R. Lee, C. Gregory
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Frontiers in Molecular Biosciences, 2023 Adenocarcinoma not otherwise specified (AC) and mucinous adenocarcinoma (MC) have different biological behaviors and clinical features. We utilized our previous proteomic data and public transcriptome, single-cell transcriptome, and spatial transcriptome
Kailun Xu +4 more
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Age-related functional changes in hematopoietic microenvironment
Journal of Physical Fitness and Sports Medicine, 2016 The hematopoietic microenvironment composed of stromal cells strictly regulates hematopoietic stem cells and hematopoietic progenitor cells by producing positive- and negative-regulators to supply mature hematopoietic cells to the periphery throughout ...
Isao Tsuboi +2 more
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The oncostatin M‐stromal cell axis in health and disease
Scandinavian Journal of Immunology, 2018 The field of stromal immunology has risen to prominence in the last decade, fuelled by accumulating evidence that nonhaematopoietic mesenchymal cells are not simply involved in modulating tissue structure, but actively contribute to immune processes.
Nathan R. West, B. M. Owens, A. Hegazy
semanticscholar +1 more source
Stromal Cell PD-L1 Inhibits CD8+ T-cell Antitumor Immune Responses and Promotes Colon Cancer
Cancer immunology research, 2018 Mesenchymal stromal cells (MSCs) present in colorectal cancer (CRC) were found to suppress antitumor responses in vitro and in vivo via PD-1/PD-L1. The results emphasize that PD-L1 on tumor MSCs can impact the efficacy of treatments for CRC.
G. O’Malley +9 more
semanticscholar +1 more source
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source