Results 61 to 70 of about 10,735,605 (346)
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Unlocking the adenosine receptor mechanism of the tumour immune microenvironment
Frontiers in ImmunologyThe suppressive tumour microenvironment significantly hinders the efficacy of immunotherapy in treating solid tumors. In this context, stromal cells, such as tumour-associated fibroblasts, undergo changes that include an increase in the number and ...
Yecheng Han +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink +6 more
wiley +1 more source
Frontiers in ImmunologyFibrotic diseases, such as idiopathic pulmonary fibrosis (IPF) and systemic scleroderma (SSc), are commonly associated with high morbidity and mortality, thereby representing a significant unmet medical need.
Yunhao Tan +49 more
doaj +1 more source
In Vitro Effect of Neopterin on Erythropoiesis in Mice
Pteridines, 2009 Neopterin is produced by monocytes and a useful biomarker of inflammatory responses. We found recently in mice that neopterin suppressed erythropoiesis but enhanced myelopoiesis possibly by activating stromal cells, the same phenomenon observed in ...
Tsuboi Isao +4 more
doaj +1 more source
Stromal Cell Induction of Regulatory Dendritic Cells [PDF]
Frontiers in Immunology, 2012 Dendritic cells (DCs) are specialized antigen presenting cells of bone marrow origin that can exist in tissues in either an immature or mature state. DCs have a myriad of roles in immunity and tolerance induction, but are perhaps best known for their role in the activation and differentiation of naïve T cells at the onset of an acquired immune response.
Paul M. Kaye, Benjamin M. J. Owens
openaire +4 more sources
Scientific Reports, 2015 Mitochondrial activity is central to tissue homeostasis. Mitochondria dysfunction constitutes a hallmark of many genetic diseases and plays a key role in tumor progression.
A. Caicedo +11 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane +16 more
wiley +1 more source
Fibroblastic Reticular Cells Control Conduit Matrix Deposition during Lymph Node Expansion
Cell Reports, 2019 Summary: Lymph nodes (LNs) act as filters, constantly sampling peripheral cues. This is facilitated by the conduit network, a tubular structure of aligned extracellular matrix (ECM) fibrils ensheathed by fibroblastic reticular cells (FRCs).
Victor G. Martinez +13 more
doaj
ICAM1+ gingival fibroblasts modulate periodontal inflammation to mitigate bone loss
Frontiers in ImmunologyTissue-resident fibroblasts are heterogeneous and provide an endogenous source of cytokines that regulate immunologic events in many osteolytic diseases.
William S. Kim +8 more
doaj +1 more source