Results 71 to 80 of about 10,735,605 (346)

AKI Recovery Induced by Mesenchymal Stromal Cell-Derived Extracellular Vesicles Carrying MicroRNAs.

Journal of the American Society of Nephrology, 2015
Phenotypic changes induced by extracellular vesicles have been implicated in mesenchymal stromal cell-promoted recovery of AKI. MicroRNAs are potential candidates for cell reprogramming toward a proregenerative phenotype.
F. Collino, S. Bruno, Danny Incarnato, Daniela Dettori, F. Neri, P. Provero, M. Pomatto, S. Oliviero, C. Tetta, P. Quesenberry, G. Camussi   +10 more
semanticscholar   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Gut Mesenchymal Stromal Cells in Immunity [PDF]

Stem Cells International, 2017
Mesenchymal stromal cells (MSCs), first found in bone marrow (BM), are the structural architects of all organs, participating in most biological functions. MSCs possess tissue-specific signatures that allow their discrimination according to their origin and location. Among their multiple functions, MSCs closely interact with immune cells, orchestrating
Messina V., Buccione C., Marotta G., Ziccheddu G., Signore M., Mattia G., Puglisi R., Sacchetti B., Biancone L., Valtieri M.   +9 more
openaire   +3 more sources

Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer

Nature Communications, 2018
The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies.
Aurélie S. Cazet, M. Hui, Benjamin L. Elsworth, Sunny Z. Wu, D. Roden, Chia-Ling Chan, Joanna N. Skhinas, R. Collot, Jessica Yang, K. Harvey, M. Z. Johan, C. Cooper, Radhika Nair, D. Herrmann, Andrea Mcfarland, N. Deng, M. Ruíz-Borrego, F. Rojo, José M. Trigo, S. Bezares, R. Caballero, E. Lim, P. Timpson, S. O'toole, D. N. Watkins, Thomas R. Cox, M. Samuel, Miguel Martín, A. Swarbrick   +28 more
semanticscholar   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Mesenchymal Stem/Stromal Cells in Stromal Evolution and Cancer Progression [PDF]

Stem Cells International, 2015
The study of cancer biology has mainly focused on malignant epithelial cancer cells, although tumors also contain a stromal compartment, which is composed of stem cells, tumor‐associated fibroblasts (TAFs), endothelial cells, immune cells, adipocytes, cytokines, and various types of macromolecules comprising the extracellular matrix (ECM).
Cammarota F, Laukkanen M
openaire   +4 more sources

Stromal cells maintain immune cell homeostasis in adipose tissue via production of interleukin-33

Science immunology, 2019
Tissue-resident stromal cells control innate lymphoid cell–dependent immune homeostasis in adipose tissue. Stromal sources of IL-33 in fat depots White adipose tissue (WAT) is home to Tregs and group 2 innate lymphoid cells (ILC2s) that help keep ...
Tanel Mahlakõiv, A. Flamar, L. Johnston, Saya Moriyama, G. Putzel, P. Bryce, D. Artis   +6 more
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells

Nature Cell Biology, 2018
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and buffer the negative effects of environmental changes. Extracellular microRNAs (miRNAs) have recently been implicated in the intercellular crosstalk.
Wei Yan, Xiwei Wu, Weiying Zhou, M. Fong, Minghui Cao, Juan Liu, Xiaojing Liu, Chih-Hong Chen, O. Fadare, D. Pizzo, Jiawen Wu, Liang Liu, Xuxiang Liu, Andrew R. Chin, X. Ren, Yuan Chen, J. Locasale, Shizhen Emily Wang   +17 more
semanticscholar   +1 more source